Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1

Obesity is associated with increased risk of cardiovascular disease, but underlying mechanisms remain elusive. Metabolic dysfunction, especially hyperglycemia, is thought to be a major contributor, but how glucose impacts vascular function is unclear. GAL3 (galectin-3) is a sugar-binding lectin upre...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2023-10, Vol.43 (10), p.e381-e395
Hauptverfasser:	Padgett, Caleb A, Bátori, Róbert K, Speese, Andrew C, Rosewater, Cody L, Bush, Weston B, Derella, Cassandra C, Haigh, Stephen B, Sellers, Hunter G, Corley, Zachary L, West, Madison A, Mintz, James D, Ange, Brittany B, Harris, Ryan A, Brands, Michael W, Fulton, David J R, Stepp, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Diseases Endothelial Cells - metabolism Endothelium, Vascular - metabolism Galectin 3 - genetics Galectin 3 - metabolism Humans Hyperglycemia - metabolism Hypertension Mice Mice, Knockout Mice, Obese NADPH Oxidase 1 - metabolism NADPH Oxidases - metabolism Obesity - complications Obesity - genetics Obesity - metabolism Oxidative Stress
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