Central Compartment Atopic Disease and Its Surgical Outcomes: Olfactory Changes and Technical Notes

Background Central compartment atopic disease (CCAD) is a recent, novel phenotype of chronic rhinosinusitis. Only a few studies have assessed olfactory function in patients with CCAD. Objectives We aimed to investigate olfactory function changes after functional endoscopic sinus surgery (FESS) in pa...

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Veröffentlicht in:Allergy & rhinology (Providence, R.I.) R.I.), 2023-01, Vol.14, p.27534030231217423-27534030231217423
Hauptverfasser: Huang, Sheng-Kai, Hsieh, Ching-Hung, Weng, Ming-Chian, Lai, Jen-Tsung, Shen, Ping-Hung
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Sprache:eng
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Zusammenfassung:Background Central compartment atopic disease (CCAD) is a recent, novel phenotype of chronic rhinosinusitis. Only a few studies have assessed olfactory function in patients with CCAD. Objectives We aimed to investigate olfactory function changes after functional endoscopic sinus surgery (FESS) in patients with CCAD and proposed some surgical techniques to enhance the postoperative olfactory outcomes in such patients. Design A retrospective cohort study. Methods We collected data from 23 patients (8 men and 15 women) with CCAD who underwent FESS performed by a surgeon in Taiwan, between June 2018 and December 2021. The demographic data, olfactory function, and serum and tissue eosinophil percentages of the included patients were analyzed. The Top International Biotech Smell Identification Test (TIBSIT; Top International Biotech, Taipei, Taiwan) was used to assess olfactory function. Results Of the 23 patients, most (95%) showed a positive reaction to aeroallergens, and 2 patients (8.7%) had asthma. Ten patients (43.5%) had peripheral eosinophilia, and 9 (39%) had eosinophilic nasal polyps. Moreover, the patients presented with variable olfactory dysfunction; the mean preoperative TIBSIT (pr-TIBSIT) score was 12.8 ± 2.3 (range: 0-43), whereas the mean postoperative TIBSIT (po-TIBSIT) score was 29.2 ± 1.9 (range: 16-44). The po-TIBSIT score was significantly better than the pre-TIBSIT score (paired t test, P 
ISSN:2753-4030
2152-6575
2753-4030
2152-6567
DOI:10.1177/27534030231217423