cAMP competitively inhibits periplasmic phosphatases to coordinate nutritional growth with competence of Haemophilus influenzae

Most naturally competent bacteria tightly regulate the window of the competent state to maximize their ecological fitness under specific conditions. Development of competence by Haemophilus influenzae strain Rd KW20 is stimulated by cAMP and inhibited by purine nucleotides, respectively. In contrast...

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Veröffentlicht in:	The Journal of biological chemistry 2023-12, Vol.299 (12), p.105404, Article 105404
Hauptverfasser:	Kronborg, Kristina, Zhang, Yong Everett
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism AphA Bacterial Proteins - genetics Bacterial Proteins - metabolism cAMP Cyclic AMP - metabolism e(P4) Haemophilus influenzae Haemophilus influenzae - genetics Haemophilus influenzae - metabolism hel NAD NAD - metabolism NadN natural competence NMN nucleoside nucleotide periplasmic acid phosphatase Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Purine Nucleotides - metabolism
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