An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions

Colonization of the gut and airways by pathogenic bacteria can lead to local tissue destruction and life-threatening systemic infections, especially in immunologically compromised individuals. Here, we describe an mRNA-based platform enabling delivery of pathogen-specific immunoglobulin A (IgA) mono...

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Veröffentlicht in:	Cell reports. Medicine 2023-11, Vol.4 (11), p.101253-101253, Article 101253
Hauptverfasser:	Deal, Cailin E, Richards, Angelene F, Yeung, Tracy, Maron, Max J, Wang, Ziqiu, Lai, Yen-Ting, Fritz, Brian R, Himansu, Sunny, Narayanan, Elisabeth, Liu, Ding, Koleva, Rositsa, Licht, Stuart, Hsiao, Chiaowen J, Rajlic, Ivana L, Koch, Hillary, Kleyman, Michael, Pulse, Mark E, Weiss, William J, Doering, Jennifer E, Lindberg, Samantha K, Mantis, Nicholas J, Carfi, Andrea, Plante, Obadiah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Immunoglobulin A Mice Mucous Membrane Peyer's Patches
Online-Zugang:	Volltext
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