Vasculature organotropism in drug delivery
[Display omitted] Over the past decades, there has been an exponential increase in the development of preclinical and clinical nanodelivery systems, and recently, an accelerating demand to deliver RNA and protein-based therapeutics. Organ-specific vasculature provides a promising intermediary for si...
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| Veröffentlicht in: | Advanced drug delivery reviews 2023-10, Vol.201, p.115054-115054, Article 115054 |
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| container_title | Advanced drug delivery reviews |
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| creator | Amruta, A Iannotta, Dalila Cheetham, Seth W. Lammers, Twan Wolfram, Joy |
| description | [Display omitted]
Over the past decades, there has been an exponential increase in the development of preclinical and clinical nanodelivery systems, and recently, an accelerating demand to deliver RNA and protein-based therapeutics. Organ-specific vasculature provides a promising intermediary for site-specific delivery of nanoparticles and extracellular vesicles to interstitial cells. Endothelial cells express organ-specific surface marker repertoires that can be used for targeted delivery. This article highlights organ-specific vasculature properties, nanodelivery strategies that exploit vasculature organotropism, and overlooked challenges and opportunities in targeting and simultaneously overcoming the endothelial barrier. Impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed. |
| doi_str_mv | 10.1016/j.addr.2023.115054 |
| format | Article |
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Over the past decades, there has been an exponential increase in the development of preclinical and clinical nanodelivery systems, and recently, an accelerating demand to deliver RNA and protein-based therapeutics. Organ-specific vasculature provides a promising intermediary for site-specific delivery of nanoparticles and extracellular vesicles to interstitial cells. Endothelial cells express organ-specific surface marker repertoires that can be used for targeted delivery. This article highlights organ-specific vasculature properties, nanodelivery strategies that exploit vasculature organotropism, and overlooked challenges and opportunities in targeting and simultaneously overcoming the endothelial barrier. Impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed.</description><identifier>ISSN: 0169-409X</identifier><identifier>ISSN: 1872-8294</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2023.115054</identifier><identifier>PMID: 37591370</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Drug Carriers ; Drug delivery ; Drug Delivery Systems ; Endothelial barrier ; Endothelial Cells ; Extracellular vesicles ; Humans ; Nanodelivery ; Nanoparticle Drug Delivery System ; Nanoparticles ; Organ-specific</subject><ispartof>Advanced drug delivery reviews, 2023-10, Vol.201, p.115054-115054, Article 115054</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-e96f20bc5aad4f819bd9490ffcc28211dff521219d4996070ddadd283d0dd8593</citedby><cites>FETCH-LOGICAL-c456t-e96f20bc5aad4f819bd9490ffcc28211dff521219d4996070ddadd283d0dd8593</cites><orcidid>0000-0002-1090-6805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.addr.2023.115054$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37591370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amruta, A</creatorcontrib><creatorcontrib>Iannotta, Dalila</creatorcontrib><creatorcontrib>Cheetham, Seth W.</creatorcontrib><creatorcontrib>Lammers, Twan</creatorcontrib><creatorcontrib>Wolfram, Joy</creatorcontrib><title>Vasculature organotropism in drug delivery</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>[Display omitted]
Over the past decades, there has been an exponential increase in the development of preclinical and clinical nanodelivery systems, and recently, an accelerating demand to deliver RNA and protein-based therapeutics. Organ-specific vasculature provides a promising intermediary for site-specific delivery of nanoparticles and extracellular vesicles to interstitial cells. Endothelial cells express organ-specific surface marker repertoires that can be used for targeted delivery. This article highlights organ-specific vasculature properties, nanodelivery strategies that exploit vasculature organotropism, and overlooked challenges and opportunities in targeting and simultaneously overcoming the endothelial barrier. Impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed.</description><subject>Drug Carriers</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Endothelial barrier</subject><subject>Endothelial Cells</subject><subject>Extracellular vesicles</subject><subject>Humans</subject><subject>Nanodelivery</subject><subject>Nanoparticle Drug Delivery System</subject><subject>Nanoparticles</subject><subject>Organ-specific</subject><issn>0169-409X</issn><issn>1872-8294</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEYRYMotlb_gAuZpQgz5jWPgCBSfEHBjYq7kOZRU2YmNZkp9N-bMrXoxtUX-M69SQ4A5whmCKLiepkJpXyGISYZQjnM6QEYo6rEaYUZPQTjCLGUQvYxAichLCFEuCzgMRiRMmeIlHAMrt5FkH0tut7rxPmFaF3n3cqGJrFtony_SJSu7Vr7zSk4MqIO-mw3J-Dt4f51-pTOXh6fp3ezVNK86FLNCoPhXOZCKGoqxOaKUQaNkRJXGCFlTI4RRkxRxgpYQqXiN3BFVDxVOSMTcDv0rvp5o5XUbedFzVfeNsJvuBOW_9209pMv3JojWDDCCI0Nl7sG7756HTre2CB1XYtWuz5wXOWEUQRLHFE8oNK7ELw2-3sQ5FvLfMm3lvnWMh8sx9DF7xfuIz9aI3AzADp6WlvteZBWt1Ir67XsuHL2v_5v1wqOvg</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Amruta, A</creator><creator>Iannotta, Dalila</creator><creator>Cheetham, Seth W.</creator><creator>Lammers, Twan</creator><creator>Wolfram, Joy</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1090-6805</orcidid></search><sort><creationdate>20231001</creationdate><title>Vasculature organotropism in drug delivery</title><author>Amruta, A ; Iannotta, Dalila ; Cheetham, Seth W. ; Lammers, Twan ; Wolfram, Joy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-e96f20bc5aad4f819bd9490ffcc28211dff521219d4996070ddadd283d0dd8593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Drug Carriers</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Endothelial barrier</topic><topic>Endothelial Cells</topic><topic>Extracellular vesicles</topic><topic>Humans</topic><topic>Nanodelivery</topic><topic>Nanoparticle Drug Delivery System</topic><topic>Nanoparticles</topic><topic>Organ-specific</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amruta, A</creatorcontrib><creatorcontrib>Iannotta, Dalila</creatorcontrib><creatorcontrib>Cheetham, Seth W.</creatorcontrib><creatorcontrib>Lammers, Twan</creatorcontrib><creatorcontrib>Wolfram, Joy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amruta, A</au><au>Iannotta, Dalila</au><au>Cheetham, Seth W.</au><au>Lammers, Twan</au><au>Wolfram, Joy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasculature organotropism in drug delivery</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>201</volume><spage>115054</spage><epage>115054</epage><pages>115054-115054</pages><artnum>115054</artnum><issn>0169-409X</issn><issn>1872-8294</issn><eissn>1872-8294</eissn><abstract>[Display omitted]
Over the past decades, there has been an exponential increase in the development of preclinical and clinical nanodelivery systems, and recently, an accelerating demand to deliver RNA and protein-based therapeutics. Organ-specific vasculature provides a promising intermediary for site-specific delivery of nanoparticles and extracellular vesicles to interstitial cells. Endothelial cells express organ-specific surface marker repertoires that can be used for targeted delivery. This article highlights organ-specific vasculature properties, nanodelivery strategies that exploit vasculature organotropism, and overlooked challenges and opportunities in targeting and simultaneously overcoming the endothelial barrier. Impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37591370</pmid><doi>10.1016/j.addr.2023.115054</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1090-6805</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2023-10, Vol.201, p.115054-115054, Article 115054 |
| issn | 0169-409X 1872-8294 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Drug Carriers Drug delivery Drug Delivery Systems Endothelial barrier Endothelial Cells Extracellular vesicles Humans Nanodelivery Nanoparticle Drug Delivery System Nanoparticles Organ-specific |
| title | Vasculature organotropism in drug delivery |
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