P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway

Aims Purinergic signaling-mediated mitochondria dysfunction and innate immune-mediated inflammation act as triggers during acetaminophen (APAP)-induced liver injury (AILI). However, the underlying mechanisms by which purinoceptor regulates mitochondria function and inflammation response in the progr...

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Veröffentlicht in:	Cell biology and toxicology 2023-12, Vol.39 (6), p.2761-2774
Hauptverfasser:	Yu, Yeping, Chang, Ling, Hu, Qingluan, Zhu, Jianjun, Zhang, Jianjun, Xia, Qiang, Zhao, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - adverse effects Analgesics Analgesics, Non-Narcotic - metabolism Animals Biochemistry Biomedical and Life Sciences Cell Biology Cell death Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury, Chronic - metabolism Depletion Humans Inflammation Inflammation - metabolism Injuries Kinases Life Sciences Liver Liver Failure, Acute - metabolism Mice Mice, Inbred C57BL Mitochondria Pharmacology/Toxicology Purine P2X receptors Signal Transduction Stimulators
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