Identification of novel plant cysteine oxidase inhibitors from a yeast chemical genetic screen

Hypoxic responses in plants involve Plant Cysteine Oxidases (PCOs). They catalyze the N-terminal cysteine oxidation of Ethylene Response Factors VII (ERF-VII) in an oxygen-dependent manner, leading to their degradation via the cysteine N-degron pathway (Cys-NDP) in normoxia. In hypoxia, PCO activity...

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Veröffentlicht in:	The Journal of biological chemistry 2023-12, Vol.299 (12), p.105366-105366, Article 105366
Hauptverfasser:	Lavilla-Puerta, Mikel, Latter, Rebecca, Bellè, Francesca, Cervelli, Tiziana, Galli, Alvaro, Perata, Pierdomenico, Chini, Andrea, Flashman, Emily, Giuntoli, Beatrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobiosis Arabidopsis - drug effects Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana chemical genetics Cysteine - metabolism Cysteine Dioxygenase - antagonists & inhibitors Cysteine Dioxygenase - metabolism Degrons Drug Evaluation, Preclinical - methods Enzyme Activation - drug effects enzyme inhibitor Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology ERF-VII Gene Expression Regulation, Plant - drug effects high-throughput screening (HTS) Humans hypoxia low oxygen stress priming Oxygen - metabolism plant cysteine oxidase Recombinant Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Seedlings - drug effects Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology yeast
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