MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival

The MYC oncogenic transcription factor is acetylated by the p300 and GCN5 histone acetyltransferases. The significance of MYC acetylation and the functions of specific acetylated lysine (AcK) residues have remained unclear. Here, we show that the major p300-acetylated K148(149) and K157(158) sites i...

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Veröffentlicht in:	Genes & development 2023-10, Vol.37 (19-20), p.865-882
Hauptverfasser:	Hurd, Matthew, Pino, Jeffrey, Jang, Kay, Allevato, Michael M, Vorontchikhina, Marina, Ichikawa, Wataru, Zhao, Yifan, Gates, Ryan, Villalpando, Emily, Hamilton, Michael J, Faiola, Francesco, Pan, Songqin, Qi, Yue, Hung, Yu-Wen, Girke, Thomas, Ann, David, Seewaldt, Victoria, Martinez, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cell Adhesion - genetics Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics Histone Acetyltransferases - metabolism Humans Lysine - metabolism Mice Research Papers
Online-Zugang:	Volltext
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