A Novel mechanism of herbicide action through disruption of pyrimidine biosynthesis

A lead aryl pyrrolidinone anilide identified using high-throughput in vivo screening was optimized for efficacy, crop safety, and weed spectrum, resulting in tetflupyrolimet. Known modes of action were ruled out through in vitro enzyme and in vivo plant-based assays. Genomic sequencing of aryl pyrro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-11, Vol.120 (48), p.e2313197120-e2313197120
Hauptverfasser:	Kang, Il-Ho, Emptage, Ryan P, Kim, Sang-Ic, Gutteridge, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides Aromatic compounds Binding sites Biological Sciences Biosynthesis Dihydroorotate Dehydrogenase Enzyme Inhibitors - pharmacology Enzymes Herbicides Herbicides - pharmacology Metabolomics Mode of action Oxidoreductases Acting on CH-CH Group Donors - metabolism Pyrimidines - pharmacology Pyrrolidinones
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