Characterization and biodistribution of under-employed gene therapy vector AAV7

AAV7 is a clade D adeno-associated virus (AAV) whose potential as a gene therapy vector has not been fully evaluated. We show here that high-titer AAV7 vectors can be produced in HEK293 cells and used to transduce cultured cells in an AAV receptor (AAVR)-dependent manner. In contrast with AAV9, AAV7...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of virology 2023-11, Vol.97 (11), p.e0116323-e0116323
Hauptverfasser:	Yost, Samantha A., Firlar, Emre, Glenn, Justin D., Carroll, Hayley B., Foltz, Steven, Giles, April R., Egley, Jenny M., Firnberg, Elad, Cho, Sungyeon, Nguyen, Trang, Henry, William M., Janczura, Karolina J., Bruder, Joseph, Liu, Ye, Danos, Olivier, Karumuthil-Melethil, Subha, Pannem, Sanjana, Yost, Valerie, Engelson, Yelena, Kaelber, Jason T., Dimant, Hemi, Smith, Jared B., Mercer, Andrew C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Delivery
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!