Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity, and neutralization sensitivity

The Omicron subvariants have substantially evaded host-neutralizing antibodies and adopted an endosomal route of entry. The virus has acquired several mutations in the receptor binding domain and N-terminal domain of S1 subunit, but remarkably, also incorporated mutations in S2 which are fixed in Om...

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Veröffentlicht in:	Journal of virology 2023-11, Vol.97 (11), p.e0092223
Hauptverfasser:	Kumar, Sahil, Delipan, Rathina, Chakraborty, Debajyoti, Kanjo, Kawkab, Singh, Randhir, Singh, Nittu, Siddiqui, Samreen, Tyagi, Akansha, Jha, Vinitaa, Thakur, Krishan G, Pandey, Rajesh, Varadarajan, Raghavan, Ringe, Rajesh P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing Antibodies, Viral COVID-19 Endopeptidases Humans Molecular Conformation Mutation Peptide Hydrolases SARS-CoV-2 - classification SARS-CoV-2 - genetics Spike Glycoprotein, Coronavirus - genetics Virus-Cell Interactions
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