“Boundary residues” between the folded RNA recognition motif and disordered RGG domains are critical for FUS–RNA binding

Fused in sarcoma (FUS) is an abundant RNA-binding protein, which drives phase separation of cellular condensates and plays multiple roles in RNA regulation. The RNA-binding ability of FUS protein is crucial to its cellular function. Here, our molecular simulation study on the FUS–RNA complex provide...

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Veröffentlicht in:	The Journal of biological chemistry 2023-12, Vol.299 (12), p.105392, Article 105392
Hauptverfasser:	Balasubramanian, Sangeetha, Maharana, Shovamayee, Srivastava, Anand
Format:	Artikel
Sprache:	eng
Schlagworte:	fused in sarcoma low-complexity domain molecular simulations RNA recognition motif RNA–FUS binding
Online-Zugang:	Volltext
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