Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion
Introduction: Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing. Patients and methods: Consecutive CRAO patients with D...
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| Veröffentlicht in: | European stroke journal 2023-12, Vol.8 (4), p.974-981 |
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| creator | Lange, Kristin Sophie Mourand, Isabelle Coget, Arthur Menjot de Champfleur, Nicolas Ayrignac, Xavier Arquizan, Caroline Scheel, Michael Bohner, Georg Villringer, Kersten Zagroun, Charlie Siebert, Eberhard Danyel, Leon Alexander |
| description | Introduction:
Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing.
Patients and methods:
Consecutive CRAO patients with DWI performed within 24 h after onset of visual impairment were included in a bicentric, retrospective cross-sectional study. Two blinded neuroradiologists assessed randomized DWI scans for the presence of retinal ischemia. RDR detection rates, false positive ratings, and interrater agreement were evaluated for predefined time groups.
Results:
Sixty eight CRAO patients (68.4 ± 16.8 years; 25 female) with 72 DWI scans (76.4% 3 T, 23.6% 1.5 T) were included. Mean time-delay between onset of CRAO and DWI acquisition was 13.4 ± 7.0 h. Overall RDR detection rates ranged from 52.8% to 62.5% with false positive ratings in 4.2%–8.3% of cases. RDR detection rates were higher in DWI performed 12–24 h after onset, when compared with DWI acquired within the first 12 h (79.5%vs 39.3%, p |
| doi_str_mv | 10.1177/23969873231190716 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10683725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_23969873231190716</sage_id><sourcerecordid>2893834704</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-de9450256f43978b8780811254fe30c77bb547c020375a2b60c82cc927d00f1f3</originalsourceid><addsrcrecordid>eNp9UU1LAzEQDaJYUX-Atz16Wc3H7iY5ifgNghfFY8imk23KNqnJrtJ_b2pLQQRPb5h5781jBqEzgi8I4fySMtlIwRllhEjMSbOHjta9UgpB9nc1ZxN0mtIcY0wkaZggh2jCuJQ8l0fo_dZZOyYXfPkFrpsNMC0WuvMwOFNESMFrb6Bwued8VzhfgI79qjDgh6j7TBmcz6jjAHFVBGP6H7cTdGB1n-B0i8fo7f7u9eaxfH55eLq5fi4Na8RQTkFWNaZ1YysmuWgFF1gQQuvKAsOG87atK24wxYzXmrYNNoIaIymfYmyJZcfoauO7HNsFTLex1DLmxHGlgnbq98S7merCpyK4EYzTOjucbx1i-BghDWrhkoG-1x7CmBQVkglWcVxlKtlQTQwpRbC7PQSr9VPUn6dkzcVGk3QHah7GmM-V_hF8A4ASi3o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2893834704</pqid></control><display><type>article</type><title>Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion</title><source>Access via SAGE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Lange, Kristin Sophie ; Mourand, Isabelle ; Coget, Arthur ; Menjot de Champfleur, Nicolas ; Ayrignac, Xavier ; Arquizan, Caroline ; Scheel, Michael ; Bohner, Georg ; Villringer, Kersten ; Zagroun, Charlie ; Siebert, Eberhard ; Danyel, Leon Alexander</creator><creatorcontrib>Lange, Kristin Sophie ; Mourand, Isabelle ; Coget, Arthur ; Menjot de Champfleur, Nicolas ; Ayrignac, Xavier ; Arquizan, Caroline ; Scheel, Michael ; Bohner, Georg ; Villringer, Kersten ; Zagroun, Charlie ; Siebert, Eberhard ; Danyel, Leon Alexander</creatorcontrib><description>Introduction:
Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing.
Patients and methods:
Consecutive CRAO patients with DWI performed within 24 h after onset of visual impairment were included in a bicentric, retrospective cross-sectional study. Two blinded neuroradiologists assessed randomized DWI scans for the presence of retinal ischemia. RDR detection rates, false positive ratings, and interrater agreement were evaluated for predefined time groups.
Results:
Sixty eight CRAO patients (68.4 ± 16.8 years; 25 female) with 72 DWI scans (76.4% 3 T, 23.6% 1.5 T) were included. Mean time-delay between onset of CRAO and DWI acquisition was 13.4 ± 7.0 h. Overall RDR detection rates ranged from 52.8% to 62.5% with false positive ratings in 4.2%–8.3% of cases. RDR detection rates were higher in DWI performed 12–24 h after onset, when compared with DWI acquired within the first 12 h (79.5%vs 39.3%, p < 0.001). The share of false positive ratings was highest for DWI performed within the first 6 h of symptom onset (up to 14.3%). Interrater reliability was “moderate” for DWI performed within the first 18 h (κ = 0.57–0.58), but improved for DWI acquired between 18 and 24 h (κ = 0.94).
Conclusion:
DWI-based detection of retinal ischemia in early CRAO is likely to be time-dependent with superior diagnostic accuracy for DWI performed 12–24 h after onset of visual impairment.
Graphical abstract</description><identifier>ISSN: 2396-9873</identifier><identifier>EISSN: 2396-9881</identifier><identifier>DOI: 10.1177/23969873231190716</identifier><identifier>PMID: 37997381</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Original s</subject><ispartof>European stroke journal, 2023-12, Vol.8 (4), p.974-981</ispartof><rights>European Stroke Organisation 2023</rights><rights>European Stroke Organisation 2023 2023 European Stroke Organisation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-de9450256f43978b8780811254fe30c77bb547c020375a2b60c82cc927d00f1f3</cites><orcidid>0000-0002-8056-8514 ; 0000-0001-9798-5325</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683725/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683725/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,21819,27924,27925,43621,43622,53791,53793</link.rule.ids></links><search><creatorcontrib>Lange, Kristin Sophie</creatorcontrib><creatorcontrib>Mourand, Isabelle</creatorcontrib><creatorcontrib>Coget, Arthur</creatorcontrib><creatorcontrib>Menjot de Champfleur, Nicolas</creatorcontrib><creatorcontrib>Ayrignac, Xavier</creatorcontrib><creatorcontrib>Arquizan, Caroline</creatorcontrib><creatorcontrib>Scheel, Michael</creatorcontrib><creatorcontrib>Bohner, Georg</creatorcontrib><creatorcontrib>Villringer, Kersten</creatorcontrib><creatorcontrib>Zagroun, Charlie</creatorcontrib><creatorcontrib>Siebert, Eberhard</creatorcontrib><creatorcontrib>Danyel, Leon Alexander</creatorcontrib><title>Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion</title><title>European stroke journal</title><description>Introduction:
Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing.
Patients and methods:
Consecutive CRAO patients with DWI performed within 24 h after onset of visual impairment were included in a bicentric, retrospective cross-sectional study. Two blinded neuroradiologists assessed randomized DWI scans for the presence of retinal ischemia. RDR detection rates, false positive ratings, and interrater agreement were evaluated for predefined time groups.
Results:
Sixty eight CRAO patients (68.4 ± 16.8 years; 25 female) with 72 DWI scans (76.4% 3 T, 23.6% 1.5 T) were included. Mean time-delay between onset of CRAO and DWI acquisition was 13.4 ± 7.0 h. Overall RDR detection rates ranged from 52.8% to 62.5% with false positive ratings in 4.2%–8.3% of cases. RDR detection rates were higher in DWI performed 12–24 h after onset, when compared with DWI acquired within the first 12 h (79.5%vs 39.3%, p < 0.001). The share of false positive ratings was highest for DWI performed within the first 6 h of symptom onset (up to 14.3%). Interrater reliability was “moderate” for DWI performed within the first 18 h (κ = 0.57–0.58), but improved for DWI acquired between 18 and 24 h (κ = 0.94).
Conclusion:
DWI-based detection of retinal ischemia in early CRAO is likely to be time-dependent with superior diagnostic accuracy for DWI performed 12–24 h after onset of visual impairment.
Graphical abstract</description><subject>Original s</subject><issn>2396-9873</issn><issn>2396-9881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp9UU1LAzEQDaJYUX-Atz16Wc3H7iY5ifgNghfFY8imk23KNqnJrtJ_b2pLQQRPb5h5781jBqEzgi8I4fySMtlIwRllhEjMSbOHjta9UgpB9nc1ZxN0mtIcY0wkaZggh2jCuJQ8l0fo_dZZOyYXfPkFrpsNMC0WuvMwOFNESMFrb6Bwued8VzhfgI79qjDgh6j7TBmcz6jjAHFVBGP6H7cTdGB1n-B0i8fo7f7u9eaxfH55eLq5fi4Na8RQTkFWNaZ1YysmuWgFF1gQQuvKAsOG87atK24wxYzXmrYNNoIaIymfYmyJZcfoauO7HNsFTLex1DLmxHGlgnbq98S7merCpyK4EYzTOjucbx1i-BghDWrhkoG-1x7CmBQVkglWcVxlKtlQTQwpRbC7PQSr9VPUn6dkzcVGk3QHah7GmM-V_hF8A4ASi3o</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Lange, Kristin Sophie</creator><creator>Mourand, Isabelle</creator><creator>Coget, Arthur</creator><creator>Menjot de Champfleur, Nicolas</creator><creator>Ayrignac, Xavier</creator><creator>Arquizan, Caroline</creator><creator>Scheel, Michael</creator><creator>Bohner, Georg</creator><creator>Villringer, Kersten</creator><creator>Zagroun, Charlie</creator><creator>Siebert, Eberhard</creator><creator>Danyel, Leon Alexander</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8056-8514</orcidid><orcidid>https://orcid.org/0000-0001-9798-5325</orcidid></search><sort><creationdate>20231201</creationdate><title>Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion</title><author>Lange, Kristin Sophie ; Mourand, Isabelle ; Coget, Arthur ; Menjot de Champfleur, Nicolas ; Ayrignac, Xavier ; Arquizan, Caroline ; Scheel, Michael ; Bohner, Georg ; Villringer, Kersten ; Zagroun, Charlie ; Siebert, Eberhard ; Danyel, Leon Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-de9450256f43978b8780811254fe30c77bb547c020375a2b60c82cc927d00f1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Original s</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lange, Kristin Sophie</creatorcontrib><creatorcontrib>Mourand, Isabelle</creatorcontrib><creatorcontrib>Coget, Arthur</creatorcontrib><creatorcontrib>Menjot de Champfleur, Nicolas</creatorcontrib><creatorcontrib>Ayrignac, Xavier</creatorcontrib><creatorcontrib>Arquizan, Caroline</creatorcontrib><creatorcontrib>Scheel, Michael</creatorcontrib><creatorcontrib>Bohner, Georg</creatorcontrib><creatorcontrib>Villringer, Kersten</creatorcontrib><creatorcontrib>Zagroun, Charlie</creatorcontrib><creatorcontrib>Siebert, Eberhard</creatorcontrib><creatorcontrib>Danyel, Leon Alexander</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European stroke journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lange, Kristin Sophie</au><au>Mourand, Isabelle</au><au>Coget, Arthur</au><au>Menjot de Champfleur, Nicolas</au><au>Ayrignac, Xavier</au><au>Arquizan, Caroline</au><au>Scheel, Michael</au><au>Bohner, Georg</au><au>Villringer, Kersten</au><au>Zagroun, Charlie</au><au>Siebert, Eberhard</au><au>Danyel, Leon Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion</atitle><jtitle>European stroke journal</jtitle><date>2023-12-01</date><risdate>2023</risdate><volume>8</volume><issue>4</issue><spage>974</spage><epage>981</epage><pages>974-981</pages><issn>2396-9873</issn><eissn>2396-9881</eissn><abstract>Introduction:
Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing.
Patients and methods:
Consecutive CRAO patients with DWI performed within 24 h after onset of visual impairment were included in a bicentric, retrospective cross-sectional study. Two blinded neuroradiologists assessed randomized DWI scans for the presence of retinal ischemia. RDR detection rates, false positive ratings, and interrater agreement were evaluated for predefined time groups.
Results:
Sixty eight CRAO patients (68.4 ± 16.8 years; 25 female) with 72 DWI scans (76.4% 3 T, 23.6% 1.5 T) were included. Mean time-delay between onset of CRAO and DWI acquisition was 13.4 ± 7.0 h. Overall RDR detection rates ranged from 52.8% to 62.5% with false positive ratings in 4.2%–8.3% of cases. RDR detection rates were higher in DWI performed 12–24 h after onset, when compared with DWI acquired within the first 12 h (79.5%vs 39.3%, p < 0.001). The share of false positive ratings was highest for DWI performed within the first 6 h of symptom onset (up to 14.3%). Interrater reliability was “moderate” for DWI performed within the first 18 h (κ = 0.57–0.58), but improved for DWI acquired between 18 and 24 h (κ = 0.94).
Conclusion:
DWI-based detection of retinal ischemia in early CRAO is likely to be time-dependent with superior diagnostic accuracy for DWI performed 12–24 h after onset of visual impairment.
Graphical abstract</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37997381</pmid><doi>10.1177/23969873231190716</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8056-8514</orcidid><orcidid>https://orcid.org/0000-0001-9798-5325</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion |
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