Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis

Abstract Carvedilol is a widely used beta-adrenoreceptor antagonist for multiple cardiovascular indications; however, it may induce cholestasis in patients, but the mechanism for this effect is unclear. Carvedilol also prevents the development of various forms of experimental liver injury, but its e...

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Veröffentlicht in:	Toxicological sciences 2023-11, Vol.196 (2), p.200-217
Hauptverfasser:	Lastuvkova, Hana, Nova, Zuzana, Hroch, Milos, Alaei Faradonbeh, Fatemeh, Schreiberova, Jolana, Mokry, Jaroslav, Faistova, Hana, Stefela, Alzbeta, Dusek, Jan, Kucera, Otto, Hyspler, Radomír, Dohnalkova, Ester, Bayer, Rachel L, Hirsova, Petra, Pavek, Petr, Micuda, Stanislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Carvedilol - metabolism Carvedilol - pharmacology Homeostasis Humans Liver Male Membrane Transport Proteins - metabolism Mice Mice, Inbred C57BL Molecular, Biochemical, and Systems Toxicology Non-alcoholic Fatty Liver Disease - metabolism
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