Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines

Liver fibrosis is the result of sustained chronic liver injury and inflammation leading to hepatocyte cell death followed by the formation of fibrous scars, which is the hallmark of NASH and alcoholic steatohepatitis and can lead to cirrhosis, HCC, and liver failure. Although progress has been made...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2023-11, Vol.78 (5), p.1625-1653
Hauptverfasser:	Gong, Lijun, Wei, Fang, Gonzalez, Frank J, Li, Guolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - pathology Fibrosis - etiology Fibrosis - genetics Fibrosis - metabolism Humans Inflammation - metabolism Liver - pathology Liver Cirrhosis - drug therapy Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Neoplasms - pathology Non-alcoholic Fatty Liver Disease - pathology PPAR alpha - genetics PPAR alpha - metabolism
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