Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling

Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cellular interfaces. Here, using a mechanogenetic platform that generates artificial AJs with controlled protein localization, clustering and mechanical loading, we find that AJs also organize proteolytic...

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Veröffentlicht in:	Nature cell biology 2022-12, Vol.24 (12), p.1739-1753
Hauptverfasser:	Kwak, Minsuk, Southard, Kaden M., Kim, Woon Ryoung, Lin, Annie, Kim, Nam Hyeong, Gopalappa, Ramu, Lee, Hyun Jung, An, Minji, Choi, Seo Hyun, Jung, Yunmin, Noh, Kunwoo, Farlow, Justin, Georgakopoulos, Anastasios, Robakis, Nikolaos K., Kang, Min K., Kutys, Matthew L., Seo, Daeha, Kim, Hyongbum Henry, Kim, Yong Ho, Cheon, Jinwoo, Gartner, Zev J., Jun, Young-wook
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2204/2209 631/57/2272 631/80/79/2028 631/80/86/820 Adherens junctions Alzheimer's disease Amyloid precursor protein Amyloid Precursor Protein Secretases - genetics Biomedical and Life Sciences Cancer Research Cell Biology Cell differentiation Cell surface Cells (biology) Clustering Developmental Biology Homeostasis Interfaces Life Sciences Ligands Lipids Localization Mechanical loading Membrane proteins Membranes Neural stem cells Notch protein Progenitor cells Proteins Proteolysis Receptor mechanisms Receptors Recruitment Secretase Selectivity Stem Cells Substrates Switches Ventricle Ventricular zone
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