Prognostic significance of prolonged corrected QT interval in cerebral contusion
Background & objectives: Cerebral contusion (CC) results in a release of catecholamines, autonomic dysfunction and neural stimulation that can lead to a number of cardiac adverse events, so it is critical to determine these. So the objective of this study was to investigate the prognostic signif...
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| Veröffentlicht in: | Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2023-08, Vol.158 (2), p.175-181 |
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| creator | Yavuz, Ahmed Baskurt, Ozan Kurtulus, Yunus Avci, Idris |
| description | Background & objectives: Cerebral contusion (CC) results in a release of catecholamines, autonomic dysfunction and neural stimulation that can lead to a number of cardiac adverse events, so it is critical to determine these. So the objective of this study was to investigate the prognostic significance of electrocardiographic changes, particularly the effects of a prolonged corrected QT (QTc) interval in CC.
Methods: In this retrospective cohort study, 110 patients with CC were evaluated. Age, sex, concomitant diseases, Glasgow Coma Scale on admission, radiological assessment of the contusion (location, size, course and presence of cerebral oedema), need for surgical intervention, length of hospital stay and the extended Glasgow Outcome Scale (GOS-E) were statistically analysed within the QTc interval by routine electrocardiography (ECG) on admission.
Results: The prolonged QTc interval was found to be associated with a higher incidence of cerebral oedema and a significantly higher risk of needing surgery. Patients with a prolonged QTc interval had a significantly larger contusion volume, greater midline shift and longer hospital stay, so their GOS-E score was significantly lower. A prolonged QTc interval on admission resulted in a hospital stay of more than eight days (sensitivity: 0.97 and specificity: 0.86), a higher risk of midline shift of more than 0.45 cm (P=0.006, sensitivity: 0.80 and specificity: 0.99) and a GOS-E score of |
| doi_str_mv | 10.4103/ijmr.ijmr_3629_21 |
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Methods: In this retrospective cohort study, 110 patients with CC were evaluated. Age, sex, concomitant diseases, Glasgow Coma Scale on admission, radiological assessment of the contusion (location, size, course and presence of cerebral oedema), need for surgical intervention, length of hospital stay and the extended Glasgow Outcome Scale (GOS-E) were statistically analysed within the QTc interval by routine electrocardiography (ECG) on admission.
Results: The prolonged QTc interval was found to be associated with a higher incidence of cerebral oedema and a significantly higher risk of needing surgery. Patients with a prolonged QTc interval had a significantly larger contusion volume, greater midline shift and longer hospital stay, so their GOS-E score was significantly lower. A prolonged QTc interval on admission resulted in a hospital stay of more than eight days (sensitivity: 0.97 and specificity: 0.86), a higher risk of midline shift of more than 0.45 cm (P=0.006, sensitivity: 0.80 and specificity: 0.99) and a GOS-E score of <7 (sensitivity: 0.97 and specificity: 0.85).
Interpretation & conclusions: ECG changes on admission showing a prolonged QTc interval have prognostic significance in CC. This simple and easily applicable information should be taken into consideration at the time of clinical decision making which may prevent an adverse events survivor.</description><identifier>ISSN: 0971-5916</identifier><identifier>EISSN: 0975-9174</identifier><identifier>DOI: 10.4103/ijmr.ijmr_3629_21</identifier><identifier>PMID: 37706372</identifier><language>eng</language><publisher>New Delhi: Wolters Kluwer India Pvt. Ltd</publisher><subject>Autonomic neuropathies ; Brain ; Catecholamines ; Complications and side effects ; Contusions ; Development and progression ; Edema ; Electrocardiography ; Injuries ; Long QT syndrome ; Medical research ; Medicine, Experimental ; Practice: Original ; Risk factors</subject><ispartof>Indian journal of medical research (New Delhi, India : 1994), 2023-08, Vol.158 (2), p.175-181</ispartof><rights>COPYRIGHT 2023 Medknow Publications and Media Pvt. Ltd.</rights><rights>2023. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2023 Indian Journal of Medical Research 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645032/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645032/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Yavuz, Ahmed</creatorcontrib><creatorcontrib>Baskurt, Ozan</creatorcontrib><creatorcontrib>Kurtulus, Yunus</creatorcontrib><creatorcontrib>Avci, Idris</creatorcontrib><title>Prognostic significance of prolonged corrected QT interval in cerebral contusion</title><title>Indian journal of medical research (New Delhi, India : 1994)</title><description>Background & objectives: Cerebral contusion (CC) results in a release of catecholamines, autonomic dysfunction and neural stimulation that can lead to a number of cardiac adverse events, so it is critical to determine these. So the objective of this study was to investigate the prognostic significance of electrocardiographic changes, particularly the effects of a prolonged corrected QT (QTc) interval in CC.
Methods: In this retrospective cohort study, 110 patients with CC were evaluated. Age, sex, concomitant diseases, Glasgow Coma Scale on admission, radiological assessment of the contusion (location, size, course and presence of cerebral oedema), need for surgical intervention, length of hospital stay and the extended Glasgow Outcome Scale (GOS-E) were statistically analysed within the QTc interval by routine electrocardiography (ECG) on admission.
Results: The prolonged QTc interval was found to be associated with a higher incidence of cerebral oedema and a significantly higher risk of needing surgery. Patients with a prolonged QTc interval had a significantly larger contusion volume, greater midline shift and longer hospital stay, so their GOS-E score was significantly lower. A prolonged QTc interval on admission resulted in a hospital stay of more than eight days (sensitivity: 0.97 and specificity: 0.86), a higher risk of midline shift of more than 0.45 cm (P=0.006, sensitivity: 0.80 and specificity: 0.99) and a GOS-E score of <7 (sensitivity: 0.97 and specificity: 0.85).
Interpretation & conclusions: ECG changes on admission showing a prolonged QTc interval have prognostic significance in CC. This simple and easily applicable information should be taken into consideration at the time of clinical decision making which may prevent an adverse events survivor.</description><subject>Autonomic neuropathies</subject><subject>Brain</subject><subject>Catecholamines</subject><subject>Complications and side effects</subject><subject>Contusions</subject><subject>Development and progression</subject><subject>Edema</subject><subject>Electrocardiography</subject><subject>Injuries</subject><subject>Long QT syndrome</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Practice: Original</subject><subject>Risk factors</subject><issn>0971-5916</issn><issn>0975-9174</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UluPEyEYJUbjrtUf4NskvvgylQ8YYJ7MpvGWbOKarM-EchnpTqHCzDb-e2m7blyjhgRO4JyP73IQegl4yQDTN2GzzcvDpignvSLwCJ3jXnRtD4I9PmJoux74GXpWygZj6Inon6IzKgTmVJBzdHWV0xBTmYJpShhi8MHoaFyTfLPLaUxxcLYxKWdnpoq-XDchTi7f6rGCxrjs1rlik-I0l5Dic_TE67G4F3fnAn19_-569bG9_Pzh0-risjUdkKm1AB3lHkCvjWOaWi4k8xoTRgQQ6bDtcOeZwKYyLRXSSvCd5L0U2Fu7pgv09hR3N6-3zhoXp5qH2uWw1fmHSjqohy8xfFNDulWAOeswJTXC67sIOX2fXZnUNhTjxlFHl-aiiORM9lweqa_-oG7SnGOtT1EAYAzqAP7HIlIwEJTXou9Zgx6dCtGnmp45fK0uBJcEpKzMBVr-hVWXddtQm-18qPcPBHASmJxKyc7ftwKwOrhFHY3yu1uqZnXS7NNYZ1puxnnvsqpNu4lp_2-hAtGpX8ahPwFzRMoJ</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Yavuz, Ahmed</creator><creator>Baskurt, Ozan</creator><creator>Kurtulus, Yunus</creator><creator>Avci, Idris</creator><general>Wolters Kluwer India Pvt. Ltd</general><general>Medknow Publications and Media Pvt. 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So the objective of this study was to investigate the prognostic significance of electrocardiographic changes, particularly the effects of a prolonged corrected QT (QTc) interval in CC.
Methods: In this retrospective cohort study, 110 patients with CC were evaluated. Age, sex, concomitant diseases, Glasgow Coma Scale on admission, radiological assessment of the contusion (location, size, course and presence of cerebral oedema), need for surgical intervention, length of hospital stay and the extended Glasgow Outcome Scale (GOS-E) were statistically analysed within the QTc interval by routine electrocardiography (ECG) on admission.
Results: The prolonged QTc interval was found to be associated with a higher incidence of cerebral oedema and a significantly higher risk of needing surgery. Patients with a prolonged QTc interval had a significantly larger contusion volume, greater midline shift and longer hospital stay, so their GOS-E score was significantly lower. A prolonged QTc interval on admission resulted in a hospital stay of more than eight days (sensitivity: 0.97 and specificity: 0.86), a higher risk of midline shift of more than 0.45 cm (P=0.006, sensitivity: 0.80 and specificity: 0.99) and a GOS-E score of <7 (sensitivity: 0.97 and specificity: 0.85).
Interpretation & conclusions: ECG changes on admission showing a prolonged QTc interval have prognostic significance in CC. This simple and easily applicable information should be taken into consideration at the time of clinical decision making which may prevent an adverse events survivor.</abstract><cop>New Delhi</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>37706372</pmid><doi>10.4103/ijmr.ijmr_3629_21</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autonomic neuropathies Brain Catecholamines Complications and side effects Contusions Development and progression Edema Electrocardiography Injuries Long QT syndrome Medical research Medicine, Experimental Practice: Original Risk factors |
| title | Prognostic significance of prolonged corrected QT interval in cerebral contusion |
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