Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension
The aim of the current study was to establish the interplay between blood flow patterns within a large cerebral artery and a downstream microvascular segment under conditions of transiently reduced mean arterial pressure (MAP). We report data from nine young, healthy participants (5 women; 26 ± 4 ye...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2023-10, Vol.135 (4), p.717-725 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Shoemaker, Leena N Milej, Daniel Sajid, Aleena Mistry, Jigneshkumar St Lawrence, Keith Shoemaker, J Kevin |
| description | The aim of the current study was to establish the interplay between blood flow patterns within a large cerebral artery and a downstream microvascular segment under conditions of transiently reduced mean arterial pressure (MAP). We report data from nine young, healthy participants (5 women; 26 ± 4 years) acquired during a 15 s bout of sudden-onset lower body negative pressure (LBNP; -80 mmHg). Simultaneous changes in microvascular cerebral blood flow (CBF) and middle cerebral artery blood velocity (MCAv
) were captured using diffuse correlation spectroscopy and transcranial Doppler ultrasound (TCD), respectively. Brachial blood pressure (finger photoplethysmography) and TCD waveforms were extracted at baseline and during the nadir BP response to LBNP and analyzed using a modified Windkessel model to calculate indices of cerebrovascular resistance (Ri) and compliance (Ci). Compared to baseline, rapid-onset LBNP decreased MAP by 22 ± 16% and Ri by 14 ± 10% (both P ≤ 0.03). Ci increased (322 ± 298%; P |
| doi_str_mv | 10.1152/japplphysiol.00743.2022 |
| format | Article |
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) were captured using diffuse correlation spectroscopy and transcranial Doppler ultrasound (TCD), respectively. Brachial blood pressure (finger photoplethysmography) and TCD waveforms were extracted at baseline and during the nadir BP response to LBNP and analyzed using a modified Windkessel model to calculate indices of cerebrovascular resistance (Ri) and compliance (Ci). Compared to baseline, rapid-onset LBNP decreased MAP by 22 ± 16% and Ri by 14 ± 10% (both P ≤ 0.03). Ci increased (322 ± 298%; P <0.01) but MCAv
(-8 ± 16%; P = 0.09) and CBF (-2 ± 3%; P = 0.29) were preserved. The results provide evidence that changes in both vascular resistance and compliance preserve CBF, as indexed by no significant changes in MCAv
or DCS microvascular flow, during transient hypotension.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00743.2022</identifier><identifier>PMID: 37560766</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Blood flow ; Blood pressure ; Cerebral blood flow ; Doppler effect ; Flow distribution ; Hemodynamics ; Hypotension ; Lower body negative pressure ; Microvasculature ; Spectroscopy ; Ultrasound ; Waveforms</subject><ispartof>Journal of applied physiology (1985), 2023-10, Vol.135 (4), p.717-725</ispartof><rights>Copyright American Physiological Society Oct 2023</rights><rights>Copyright © 2023 The Authors. 2023 The Authors.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-50605a19bc29f735a88e37ec8780e2f2ebabf002d9f31c1b57681689e694113a3</citedby><cites>FETCH-LOGICAL-c446t-50605a19bc29f735a88e37ec8780e2f2ebabf002d9f31c1b57681689e694113a3</cites><orcidid>0000-0002-9731-5038 ; 0000-0003-3173-0834 ; 0000-0003-3924-0717 ; 0000-0001-8022-8205 ; 0000-0002-6794-5979</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3037,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37560766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shoemaker, Leena N</creatorcontrib><creatorcontrib>Milej, Daniel</creatorcontrib><creatorcontrib>Sajid, Aleena</creatorcontrib><creatorcontrib>Mistry, Jigneshkumar</creatorcontrib><creatorcontrib>St Lawrence, Keith</creatorcontrib><creatorcontrib>Shoemaker, J Kevin</creatorcontrib><title>Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>The aim of the current study was to establish the interplay between blood flow patterns within a large cerebral artery and a downstream microvascular segment under conditions of transiently reduced mean arterial pressure (MAP). We report data from nine young, healthy participants (5 women; 26 ± 4 years) acquired during a 15 s bout of sudden-onset lower body negative pressure (LBNP; -80 mmHg). Simultaneous changes in microvascular cerebral blood flow (CBF) and middle cerebral artery blood velocity (MCAv
) were captured using diffuse correlation spectroscopy and transcranial Doppler ultrasound (TCD), respectively. Brachial blood pressure (finger photoplethysmography) and TCD waveforms were extracted at baseline and during the nadir BP response to LBNP and analyzed using a modified Windkessel model to calculate indices of cerebrovascular resistance (Ri) and compliance (Ci). Compared to baseline, rapid-onset LBNP decreased MAP by 22 ± 16% and Ri by 14 ± 10% (both P ≤ 0.03). Ci increased (322 ± 298%; P <0.01) but MCAv
(-8 ± 16%; P = 0.09) and CBF (-2 ± 3%; P = 0.29) were preserved. The results provide evidence that changes in both vascular resistance and compliance preserve CBF, as indexed by no significant changes in MCAv
or DCS microvascular flow, during transient hypotension.</description><subject>Blood flow</subject><subject>Blood pressure</subject><subject>Cerebral blood flow</subject><subject>Doppler effect</subject><subject>Flow distribution</subject><subject>Hemodynamics</subject><subject>Hypotension</subject><subject>Lower body negative pressure</subject><subject>Microvasculature</subject><subject>Spectroscopy</subject><subject>Ultrasound</subject><subject>Waveforms</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkU9v1DAQxS0EotvCVwBLXLhk8X87J4RWQJEqcYGzNXGcxqvEDnZSafvpcWmpCifbM2-e5vmH0FtK9pRK9uEIyzIt46mENO0J0YLvGWHsGdrVLmuoIvQ52hktSaOl0WfovJQjIVQISV-iM66lIlqpHbKHETK41edwC2tIEacBO599l2HCM7icGgyxx3Oo1xsobpsg49HPqT9FqNWC-y2HeI3XDLEEH1c8npa0-vpI8RV6McBU_OuH8wL9_PL5x-Gyufr-9dvh01XjhFBrI4kiEmjbOdYOmkswxnPtndGGeDYw30E3EML6duDU0U5qZagyrVetoJQDv0Af732XrZt97-oaNYBdcpghn2yCYP_txDDa63RjKVGCSaqqw_sHh5x-bb6sdg7F-WmC6NNWLDPCGMFYa6r03X_SY9pyrPmqqtq1THBRVfpeVT-ulOyHx20osXcU7VOK9g9Fe0exTr55GuZx7i82_hsXOJ8B</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Shoemaker, Leena N</creator><creator>Milej, Daniel</creator><creator>Sajid, Aleena</creator><creator>Mistry, Jigneshkumar</creator><creator>St Lawrence, Keith</creator><creator>Shoemaker, J Kevin</creator><general>American Physiological Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9731-5038</orcidid><orcidid>https://orcid.org/0000-0003-3173-0834</orcidid><orcidid>https://orcid.org/0000-0003-3924-0717</orcidid><orcidid>https://orcid.org/0000-0001-8022-8205</orcidid><orcidid>https://orcid.org/0000-0002-6794-5979</orcidid></search><sort><creationdate>20231001</creationdate><title>Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension</title><author>Shoemaker, Leena N ; Milej, Daniel ; Sajid, Aleena ; Mistry, Jigneshkumar ; St Lawrence, Keith ; Shoemaker, J Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-50605a19bc29f735a88e37ec8780e2f2ebabf002d9f31c1b57681689e694113a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood flow</topic><topic>Blood pressure</topic><topic>Cerebral blood flow</topic><topic>Doppler effect</topic><topic>Flow distribution</topic><topic>Hemodynamics</topic><topic>Hypotension</topic><topic>Lower body negative pressure</topic><topic>Microvasculature</topic><topic>Spectroscopy</topic><topic>Ultrasound</topic><topic>Waveforms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shoemaker, Leena N</creatorcontrib><creatorcontrib>Milej, Daniel</creatorcontrib><creatorcontrib>Sajid, Aleena</creatorcontrib><creatorcontrib>Mistry, Jigneshkumar</creatorcontrib><creatorcontrib>St Lawrence, Keith</creatorcontrib><creatorcontrib>Shoemaker, J Kevin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shoemaker, Leena N</au><au>Milej, Daniel</au><au>Sajid, Aleena</au><au>Mistry, Jigneshkumar</au><au>St Lawrence, Keith</au><au>Shoemaker, J Kevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>135</volume><issue>4</issue><spage>717</spage><epage>725</epage><pages>717-725</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>The aim of the current study was to establish the interplay between blood flow patterns within a large cerebral artery and a downstream microvascular segment under conditions of transiently reduced mean arterial pressure (MAP). 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) were captured using diffuse correlation spectroscopy and transcranial Doppler ultrasound (TCD), respectively. Brachial blood pressure (finger photoplethysmography) and TCD waveforms were extracted at baseline and during the nadir BP response to LBNP and analyzed using a modified Windkessel model to calculate indices of cerebrovascular resistance (Ri) and compliance (Ci). Compared to baseline, rapid-onset LBNP decreased MAP by 22 ± 16% and Ri by 14 ± 10% (both P ≤ 0.03). Ci increased (322 ± 298%; P <0.01) but MCAv
(-8 ± 16%; P = 0.09) and CBF (-2 ± 3%; P = 0.29) were preserved. The results provide evidence that changes in both vascular resistance and compliance preserve CBF, as indexed by no significant changes in MCAv
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| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Blood flow Blood pressure Cerebral blood flow Doppler effect Flow distribution Hemodynamics Hypotension Lower body negative pressure Microvasculature Spectroscopy Ultrasound Waveforms |
| title | Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension |
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