High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. In breast carcinoma, FAK overexpression has been linked to cancer progression but the prognostic relevance remains unknown. In particular, with regard to lymph node-...

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Veröffentlicht in:	Breast cancer research : BCR 2005-01, Vol.7 (2), p.R194-R203, Article R194
Hauptverfasser:	Schmitz, Klaus Jürgen, Grabellus, Florian, Callies, Rainer, Otterbach, Friedrich, Wohlschlaeger, Jeremias, Levkau, Bodo, Kimmig, Rainer, Schmid, Kurt Werner, Baba, Hideo Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Estrogen Female Focal Adhesion Kinase 1 - biosynthesis Gene Expression Profiling Humans Immunohistochemistry Lymphatic Metastasis Medical research Medicine, Experimental Middle Aged Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Oncogene Protein v-akt - metabolism Predictive Value of Tests Prognosis Receptor, ErbB-2 - physiology Risk Assessment Signal Transduction Treatment Outcome
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