Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats

Prepubertal obesity is currently an epidemic and is considered as a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance a...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2023-09, Vol.325 (3), p.F363-F376
Hauptverfasser:	Ekperikpe, Ubong S, Mandal, Sautan, Holt, Stephen J, Daniels, Jacori K, Johnson, Tyler D, Cooper, Jonita S, Safir, Sarah M, Cornelius, Denise C, Williams, Jan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Hypertension - drug therapy Hypertension - etiology Insulin Resistance Kidney Metformin - pharmacology Pediatric Obesity - complications Proteinuria - prevention & control Rats Rats, Inbred Dahl Sodium Chloride, Dietary
Online-Zugang:	Volltext
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