Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation

Abstract Background Radiation-induced secondary breast cancer (BC) may be a concern after radiation therapy (RT) for primary breast cancer (PBC), especially in young patients with germline (g)BRCA–associated BC who already have high contralateral BC (CBC) risk and potentially increased genetic susce...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2023-11, Vol.115 (11), p.1318-1328
Hauptverfasser:	van Barele, Mark, Akdeniz, Delal, Heemskerk-Gerritsen, Bernadette A M, Andrieu, Nadine, Noguès, Catherine, van Asperen, Christi J, Wevers, Marijke, Ausems, Margreet G E M, de Bock, Geertruida H, Dommering, Charlotte J, Gómez-García, Encarnacion B, van Leeuwen, Flora E, Mooij, Thea M, Easton, Douglas F, Antoniou, Antonis C, Evans, D Gareth, Izatt, Louise, Tischkowitz, Marc, Frost, Debra, Brewer, Carole, Olah, Edit, Simard, Jacques, Singer, Christian F, Thomassen, Mads, Kast, Karin, Rhiem, Kerstin, Engel, Christoph, de la Hoya, Miguel, Foretová, Lenka, Jakubowska, Anna, Jager, Agnes, Sattler, Margriet G A, Schmidt, Marjanka K, Hooning, Maartje J
Format:	Artikel
Sprache:	eng
Schlagworte:	Background radiation BRCA1 protein BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - radiotherapy Cancer therapies Chemotherapy Cohort Studies Diagnosis Endocrine therapy Female Health risks Humans Life Sciences Prospective Studies Radiation Radiation effects Radiation therapy Risk Santé publique et épidémiologie Statistical analysis Statistical models
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