Effect of Body Weight and Obesity on Esophageal Function
The incidence of obesity in the population is gradually increasing. Obesity can cause a variety of complications in the digestive system such as gastroesophageal reflux disease, and impacts the integrity of the esophageal mucosal barrier and esophageal motility. However, not many studies have focuse...
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| Veröffentlicht in: | Physiological research 2023-08, Vol.72 (4), p.525-537 |
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| description | The incidence of obesity in the population is gradually increasing. Obesity can cause a variety of complications in the digestive system such as gastroesophageal reflux disease, and impacts the integrity of the esophageal mucosal barrier and esophageal motility. However, not many studies have focused on the effect of varying degrees of obesity on the esophagus. A total of 611 participants were included in this study. We divided them into three groups according to their body mass index (BMI): the normal weight group, the overweight group, and the obesity group. We performed a retrospective comparison between groups based on indicators from high resolution esophageal manometry (HREM) and 24-hour pH impedance monitoring, and did a correlation analysis on multiple indicators such as esophageal mucosal barrier, esophageal motility, and acid reflux. The mean nocturnal baseline impedance (MNBI) in the overweight and obesity groups was lower than that in the normal group. The MNBI of the subjects in Z5-Z6 channels in the overweight group was significantly lower than that in the normal group. With respect to Z3-Z6 channels, MNBI values in the obesity group were significantly lower than those in the normal group. 'The acid exposure time (AET), the DeMeester scores (DMS) and 24-hour total reflux episodes was significantly higher in the obesity group than those in the normal and overweight groups. The upper esophageal sphincter (UES) residual pressure, and intrabolus pressure (IBP) in the overweight and obesity groups were significantly higher than those in the normal group. In addition, lower esophageal sphincter (LES) resting pressure, and esophagogastric junction contractile integral (EGJ-CI) in the obesity group were significantly higher than those in the normal group. We found that increase in body weight affected the integrity of esophageal mucosa, and different degrees of increase associated with different degrees and different aspects of changes in esophageal motility. |
| doi_str_mv | 10.33549/physiolres.935067 |
| format | Article |
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Obesity can cause a variety of complications in the digestive system such as gastroesophageal reflux disease, and impacts the integrity of the esophageal mucosal barrier and esophageal motility. However, not many studies have focused on the effect of varying degrees of obesity on the esophagus. A total of 611 participants were included in this study. We divided them into three groups according to their body mass index (BMI): the normal weight group, the overweight group, and the obesity group. We performed a retrospective comparison between groups based on indicators from high resolution esophageal manometry (HREM) and 24-hour pH impedance monitoring, and did a correlation analysis on multiple indicators such as esophageal mucosal barrier, esophageal motility, and acid reflux. The mean nocturnal baseline impedance (MNBI) in the overweight and obesity groups was lower than that in the normal group. The MNBI of the subjects in Z5-Z6 channels in the overweight group was significantly lower than that in the normal group. With respect to Z3-Z6 channels, MNBI values in the obesity group were significantly lower than those in the normal group. 'The acid exposure time (AET), the DeMeester scores (DMS) and 24-hour total reflux episodes was significantly higher in the obesity group than those in the normal and overweight groups. The upper esophageal sphincter (UES) residual pressure, and intrabolus pressure (IBP) in the overweight and obesity groups were significantly higher than those in the normal group. In addition, lower esophageal sphincter (LES) resting pressure, and esophagogastric junction contractile integral (EGJ-CI) in the obesity group were significantly higher than those in the normal group. We found that increase in body weight affected the integrity of esophageal mucosa, and different degrees of increase associated with different degrees and different aspects of changes in esophageal motility.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.935067</identifier><identifier>PMID: 37795895</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Body mass index ; Body weight ; Catheters ; Contractility ; Correlation analysis ; Digestive system ; Disease ; Endoscopy ; Esophageal sphincter ; Esophagus ; Gastroesophageal reflux ; Gastroesophageal Reflux - diagnosis ; Humans ; Motility ; Mucosa ; Obesity ; Obesity - complications ; Obesity - diagnosis ; Overweight ; Patients ; Retrospective Studies ; Software ; Sphincter ; Statistical analysis ; Swallowing</subject><ispartof>Physiological research, 2023-08, Vol.72 (4), p.525-537</ispartof><rights>Copyright Institute of Physiology 2023</rights><rights>2023 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c349t-8c8cbf823cb662ecf03738f539fef3eaa9ab932cf29252afcba35b0f9893ca463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634559/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634559/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,866,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37795895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Y</creatorcontrib><creatorcontrib>Lin, J-R</creatorcontrib><creatorcontrib>Li, Y-Q</creatorcontrib><creatorcontrib>Wei, Y-S</creatorcontrib><creatorcontrib>Duan, Z-J</creatorcontrib><title>Effect of Body Weight and Obesity on Esophageal Function</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>The incidence of obesity in the population is gradually increasing. Obesity can cause a variety of complications in the digestive system such as gastroesophageal reflux disease, and impacts the integrity of the esophageal mucosal barrier and esophageal motility. However, not many studies have focused on the effect of varying degrees of obesity on the esophagus. A total of 611 participants were included in this study. We divided them into three groups according to their body mass index (BMI): the normal weight group, the overweight group, and the obesity group. We performed a retrospective comparison between groups based on indicators from high resolution esophageal manometry (HREM) and 24-hour pH impedance monitoring, and did a correlation analysis on multiple indicators such as esophageal mucosal barrier, esophageal motility, and acid reflux. The mean nocturnal baseline impedance (MNBI) in the overweight and obesity groups was lower than that in the normal group. The MNBI of the subjects in Z5-Z6 channels in the overweight group was significantly lower than that in the normal group. With respect to Z3-Z6 channels, MNBI values in the obesity group were significantly lower than those in the normal group. 'The acid exposure time (AET), the DeMeester scores (DMS) and 24-hour total reflux episodes was significantly higher in the obesity group than those in the normal and overweight groups. The upper esophageal sphincter (UES) residual pressure, and intrabolus pressure (IBP) in the overweight and obesity groups were significantly higher than those in the normal group. In addition, lower esophageal sphincter (LES) resting pressure, and esophagogastric junction contractile integral (EGJ-CI) in the obesity group were significantly higher than those in the normal group. We found that increase in body weight affected the integrity of esophageal mucosa, and different degrees of increase associated with different degrees and different aspects of changes in esophageal motility.</description><subject>Body mass index</subject><subject>Body weight</subject><subject>Catheters</subject><subject>Contractility</subject><subject>Correlation analysis</subject><subject>Digestive system</subject><subject>Disease</subject><subject>Endoscopy</subject><subject>Esophageal sphincter</subject><subject>Esophagus</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>Humans</subject><subject>Motility</subject><subject>Mucosa</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - diagnosis</subject><subject>Overweight</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Software</subject><subject>Sphincter</subject><subject>Statistical analysis</subject><subject>Swallowing</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkE9LwzAYxoMobk6_gAcpeO5M8yZtchIdmwqDXRSPIc2StaNratIK_fYWN6ee3sPz5334IXSd4CkAo-KuKfpQusqbMBXAcJqdoHHCMYmFyOAUjTFPScwp5iN0EcIWY5LhDM7RCLJMMC7YGPG5tUa3kbPRo1v30bspN0UbqXodrXITyraPXB3Ng2sKtTGqihZdrdvS1ZfozKoqmKvDnaC3xfx19hwvV08vs4dlrIGKNuaa69xyAjpPU2K0xZABtwyENRaMUkLlAoi2RBBGlNW5ApZjK7gArWgKE3S_7226fGfW2tStV5VsfLlTvpdOlfK_UpeF3LhPmeAUKGNiaLg9NHj30ZnQyq3rfD2MloQLSlMKQAYX2bu0dyF4Y48vEiy_cctf3HKPewjd_B13jPzwhS9VT3-B</recordid><startdate>20230831</startdate><enddate>20230831</enddate><creator>Yang, Y</creator><creator>Lin, J-R</creator><creator>Li, Y-Q</creator><creator>Wei, Y-S</creator><creator>Duan, Z-J</creator><general>Institute of Physiology</general><general>Institute of Physiology of the Czech Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20230831</creationdate><title>Effect of Body Weight and Obesity on Esophageal Function</title><author>Yang, Y ; Lin, J-R ; Li, Y-Q ; Wei, Y-S ; Duan, Z-J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-8c8cbf823cb662ecf03738f539fef3eaa9ab932cf29252afcba35b0f9893ca463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body mass index</topic><topic>Body weight</topic><topic>Catheters</topic><topic>Contractility</topic><topic>Correlation analysis</topic><topic>Digestive system</topic><topic>Disease</topic><topic>Endoscopy</topic><topic>Esophageal sphincter</topic><topic>Esophagus</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>Humans</topic><topic>Motility</topic><topic>Mucosa</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - diagnosis</topic><topic>Overweight</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Software</topic><topic>Sphincter</topic><topic>Statistical analysis</topic><topic>Swallowing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Y</creatorcontrib><creatorcontrib>Lin, J-R</creatorcontrib><creatorcontrib>Li, Y-Q</creatorcontrib><creatorcontrib>Wei, Y-S</creatorcontrib><creatorcontrib>Duan, Z-J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Y</au><au>Lin, J-R</au><au>Li, Y-Q</au><au>Wei, Y-S</au><au>Duan, Z-J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Body Weight and Obesity on Esophageal Function</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2023-08-31</date><risdate>2023</risdate><volume>72</volume><issue>4</issue><spage>525</spage><epage>537</epage><pages>525-537</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>The incidence of obesity in the population is gradually increasing. Obesity can cause a variety of complications in the digestive system such as gastroesophageal reflux disease, and impacts the integrity of the esophageal mucosal barrier and esophageal motility. However, not many studies have focused on the effect of varying degrees of obesity on the esophagus. A total of 611 participants were included in this study. We divided them into three groups according to their body mass index (BMI): the normal weight group, the overweight group, and the obesity group. We performed a retrospective comparison between groups based on indicators from high resolution esophageal manometry (HREM) and 24-hour pH impedance monitoring, and did a correlation analysis on multiple indicators such as esophageal mucosal barrier, esophageal motility, and acid reflux. The mean nocturnal baseline impedance (MNBI) in the overweight and obesity groups was lower than that in the normal group. The MNBI of the subjects in Z5-Z6 channels in the overweight group was significantly lower than that in the normal group. With respect to Z3-Z6 channels, MNBI values in the obesity group were significantly lower than those in the normal group. 'The acid exposure time (AET), the DeMeester scores (DMS) and 24-hour total reflux episodes was significantly higher in the obesity group than those in the normal and overweight groups. The upper esophageal sphincter (UES) residual pressure, and intrabolus pressure (IBP) in the overweight and obesity groups were significantly higher than those in the normal group. In addition, lower esophageal sphincter (LES) resting pressure, and esophagogastric junction contractile integral (EGJ-CI) in the obesity group were significantly higher than those in the normal group. We found that increase in body weight affected the integrity of esophageal mucosa, and different degrees of increase associated with different degrees and different aspects of changes in esophageal motility.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>37795895</pmid><doi>10.33549/physiolres.935067</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Body mass index Body weight Catheters Contractility Correlation analysis Digestive system Disease Endoscopy Esophageal sphincter Esophagus Gastroesophageal reflux Gastroesophageal Reflux - diagnosis Humans Motility Mucosa Obesity Obesity - complications Obesity - diagnosis Overweight Patients Retrospective Studies Software Sphincter Statistical analysis Swallowing |
| title | Effect of Body Weight and Obesity on Esophageal Function |
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