Significant role of some miRNAs as biomarkers for the degree of obesity

Background Obesity is one of the most serious problems over the world. MicroRNAs have developed as main mediators of metabolic processes, playing significant roles in physiological processes. Thus, the present study aimed to evaluate the expressions of (miR-15a, miR-Let7, miR-344, and miR-365) and i...

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Veröffentlicht in:	Journal of Genetic Engineering and Biotechnology 2023-12, Vol.21 (1), p.109, Article 109
Hauptverfasser:	Gouda, Weaam, Ahmed, Amr E., Mageed, Lamiaa, Hassan, Amgad K., Afify, Mie, Hamimy, W. I., Ragab, Halla M., Maksoud, Nabila Abd El, Allayeh, Abdou K., Abdelmaksoud, Mohamed D. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Analysis and chemistry Apoptosis Bioinformatics Biological markers Biomarkers Biomedical Engineering and Bioengineering Biotechnology Blood Body fat Body mass index Body size Cell cycle Cholesterol Creatinine Dextrose Engineering Ethylenediaminetetraacetic acid Fasting Genetic Engineering Genetics and Genomics Glucose High density lipoprotein Liver Low density lipoprotein Low density lipoproteins Metabolism MicroRNA MicroRNAs miRNA Musculoskeletal system Obesity Physiological aspects Proteomics Statistical analysis Triglycerides Urea Variance analysis
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Zusammenfassung:	Background Obesity is one of the most serious problems over the world. MicroRNAs have developed as main mediators of metabolic processes, playing significant roles in physiological processes. Thus, the present study aimed to evaluate the expressions of (miR-15a, miR-Let7, miR-344, and miR-365) and its relationship with the different classes in obese patients. Methods A total of 125 individuals were enrolled in the study and classified into four groups: healthy non-obese controls ( n = 50), obese class I ( n = 24), obese class II ( n = 17), and obese class III ( n = 34) concerning body mass index (BMI
ISSN:	1687-157X 2090-5920
DOI:	10.1186/s43141-023-00559-w