Interleukin-22 and acute pancreatitis: A review
Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, and it is divided into 3 types according to its severity:mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. The mortality in severe acute pancreatitis is approximately 15% to 30% d...
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| Veröffentlicht in: | Medicine (Baltimore) 2023-11, Vol.102 (44), p.e35695-e35695 |
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| creator | Fu, Xinjuan Xiu, Zhigang Xu, Hongwei |
| description | Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, and it is divided into 3 types according to its severity:mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. The mortality in severe acute pancreatitis is approximately 15% to 30% due to multiorgan dysfunction and the lack of specific treatment. Interleukin-22 (IL-22) is a member of the Interleukin-10 family, and it can activate several downstream signaling pathways by binding to its receptor complex, thus it is involved in cell differentiation, proliferation, and apoptosis. Some studies have reported the elevated level of IL-22 in patients with AP, which suggests IL-22 may be involved in the pathogenesis of AP. And many studies have shown that IL-22 had a protective effect against AP. This article reviews the characteristics and mechanism of IL-22 and its role in AP to provide insight into the treatment of AP. |
| doi_str_mv | 10.1097/MD.0000000000035695 |
| format | Article |
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The mortality in severe acute pancreatitis is approximately 15% to 30% due to multiorgan dysfunction and the lack of specific treatment. Interleukin-22 (IL-22) is a member of the Interleukin-10 family, and it can activate several downstream signaling pathways by binding to its receptor complex, thus it is involved in cell differentiation, proliferation, and apoptosis. Some studies have reported the elevated level of IL-22 in patients with AP, which suggests IL-22 may be involved in the pathogenesis of AP. And many studies have shown that IL-22 had a protective effect against AP. This article reviews the characteristics and mechanism of IL-22 and its role in AP to provide insight into the treatment of AP.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000035695</identifier><identifier>PMID: 37933011</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Acute Disease ; Humans ; Interleukin-22 ; Interleukin-6 ; Interleukins ; Narrative Review ; Pancreatitis - pathology ; Severity of Illness Index</subject><ispartof>Medicine (Baltimore), 2023-11, Vol.102 (44), p.e35695-e35695</ispartof><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-dd14f708f9de91de97aacfac84f7723415f2b643bb3c0cf2e5316bffbb4cd2903</citedby><cites>FETCH-LOGICAL-c406t-dd14f708f9de91de97aacfac84f7723415f2b643bb3c0cf2e5316bffbb4cd2903</cites><orcidid>0000-0001-8118-5307</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627694/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627694/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37933011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Xinjuan</creatorcontrib><creatorcontrib>Xiu, Zhigang</creatorcontrib><creatorcontrib>Xu, Hongwei</creatorcontrib><title>Interleukin-22 and acute pancreatitis: A review</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, and it is divided into 3 types according to its severity:mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. The mortality in severe acute pancreatitis is approximately 15% to 30% due to multiorgan dysfunction and the lack of specific treatment. Interleukin-22 (IL-22) is a member of the Interleukin-10 family, and it can activate several downstream signaling pathways by binding to its receptor complex, thus it is involved in cell differentiation, proliferation, and apoptosis. Some studies have reported the elevated level of IL-22 in patients with AP, which suggests IL-22 may be involved in the pathogenesis of AP. And many studies have shown that IL-22 had a protective effect against AP. This article reviews the characteristics and mechanism of IL-22 and its role in AP to provide insight into the treatment of AP.</description><subject>Acute Disease</subject><subject>Humans</subject><subject>Interleukin-22</subject><subject>Interleukin-6</subject><subject>Interleukins</subject><subject>Narrative Review</subject><subject>Pancreatitis - pathology</subject><subject>Severity of Illness Index</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUEtLAzEQDqLYWv0FguzRy7Z5Z-NFSuuj0OJFzyGbTTS63a3Jbov_3pXW-hgYBma-x_ABcI7gEEEpRovpEP4UYVyyA9BHjPCUSU4PQR9CzFIhBe2BkxhfIUREYHoMekRIQiBCfTCaVY0NpW3ffJVinOiqSLRpG5usdGWC1Y1vfLxKxkmwa283p-DI6TLas90cgKfbm8fJfTp_uJtNxvPUUMibtCgQdQJmThZWoq6F1sZpk3VbgQlFzOGcU5LnxEDjsGUE8dy5PKemwBKSAbje6q7afGkLY6sm6FKtgl_q8KFq7dXfS-Vf1HO9VghyLLikncLlTiHU762NjVr6aGxZ6srWbVQ4yzoYggx1ULKFmlDHGKzb-yCovrJWi6n6n3XHuvj94p7zHS75BLxlegM</recordid><startdate>20231103</startdate><enddate>20231103</enddate><creator>Fu, Xinjuan</creator><creator>Xiu, Zhigang</creator><creator>Xu, Hongwei</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8118-5307</orcidid></search><sort><creationdate>20231103</creationdate><title>Interleukin-22 and acute pancreatitis: A review</title><author>Fu, Xinjuan ; Xiu, Zhigang ; Xu, Hongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-dd14f708f9de91de97aacfac84f7723415f2b643bb3c0cf2e5316bffbb4cd2903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute Disease</topic><topic>Humans</topic><topic>Interleukin-22</topic><topic>Interleukin-6</topic><topic>Interleukins</topic><topic>Narrative Review</topic><topic>Pancreatitis - pathology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xinjuan</creatorcontrib><creatorcontrib>Xiu, Zhigang</creatorcontrib><creatorcontrib>Xu, Hongwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xinjuan</au><au>Xiu, Zhigang</au><au>Xu, Hongwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-22 and acute pancreatitis: A review</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2023-11-03</date><risdate>2023</risdate><volume>102</volume><issue>44</issue><spage>e35695</spage><epage>e35695</epage><pages>e35695-e35695</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, and it is divided into 3 types according to its severity:mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. The mortality in severe acute pancreatitis is approximately 15% to 30% due to multiorgan dysfunction and the lack of specific treatment. Interleukin-22 (IL-22) is a member of the Interleukin-10 family, and it can activate several downstream signaling pathways by binding to its receptor complex, thus it is involved in cell differentiation, proliferation, and apoptosis. Some studies have reported the elevated level of IL-22 in patients with AP, which suggests IL-22 may be involved in the pathogenesis of AP. And many studies have shown that IL-22 had a protective effect against AP. This article reviews the characteristics and mechanism of IL-22 and its role in AP to provide insight into the treatment of AP.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>37933011</pmid><doi>10.1097/MD.0000000000035695</doi><orcidid>https://orcid.org/0000-0001-8118-5307</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease Humans Interleukin-22 Interleukin-6 Interleukins Narrative Review Pancreatitis - pathology Severity of Illness Index |
| title | Interleukin-22 and acute pancreatitis: A review |
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