An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration

The remodeling and stiffening of the extracellular matrix (ECM) is a well-recognized modulator of breast cancer progression. How changes in the mechanical properties of the ECM are converted into biochemical signals that direct tumor cell migration and metastasis remain poorly characterized. Here, w...

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Veröffentlicht in:	EMBO reports 2023-11, Vol.24 (11), p.e56850
Hauptverfasser:	Liang, Peigang, Zhang, Jiaqi, Wu, Yuchen, Zheng, Shanyuan, Xu, Zhaopeng, Yang, Shuo, Wang, Jinfang, Ma, Suibin, Xiao, Li, Hu, Tianhui, Jiang, Wenxue, Huang, Chaoqun, Xing, Qiong, Kundu, Mondira, Wang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Assembly Autophagy Autophagy-Related Protein-1 Homolog - genetics Autophagy-Related Protein-1 Homolog - metabolism Binding Biomaterials Biomedical materials Breast cancer Breast Neoplasms Cell adhesion & migration Cell migration Cell Movement Extracellular matrix Female Fibers Humans Intracellular Signaling Peptides and Proteins - metabolism Kinases Liquid phases Mechanical properties Mechanical stimuli Mechanotransduction Mechanotransduction, Cellular Metastases Paxillin Paxillin - metabolism Phase separation Phosphorylation Serine Serine - metabolism Src protein Stiffening Substrates Threonine Tyrosine
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