European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia
From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. Our s...
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| Veröffentlicht in: | Leukemia 2023-11, Vol.37 (11), p.2150-2167 |
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| creator | Cross, Nicholas C. P. Ernst, Thomas Branford, Susan Cayuela, Jean-Michel Deininger, Michael Fabarius, Alice Kim, Dennis Dong Hwan Machova Polakova, Katerina Radich, Jerald P. Hehlmann, Rüdiger Hochhaus, Andreas Apperley, Jane F. Soverini, Simona |
| description | From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. Our scientific and clinical knowledge underpinning these requirements continues to evolve, as do laboratory methods and technologies. The European LeukemiaNet convened an expert panel to critically consider the current status of genetic laboratory approaches to help diagnose and manage CML patients. Our recommendations focus on current best practice and highlight the strengths and pitfalls of commonly used laboratory tests. |
| doi_str_mv | 10.1038/s41375-023-02048-y |
| format | Article |
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P. ; Ernst, Thomas ; Branford, Susan ; Cayuela, Jean-Michel ; Deininger, Michael ; Fabarius, Alice ; Kim, Dennis Dong Hwan ; Machova Polakova, Katerina ; Radich, Jerald P. ; Hehlmann, Rüdiger ; Hochhaus, Andreas ; Apperley, Jane F. ; Soverini, Simona</creator><creatorcontrib>Cross, Nicholas C. P. ; Ernst, Thomas ; Branford, Susan ; Cayuela, Jean-Michel ; Deininger, Michael ; Fabarius, Alice ; Kim, Dennis Dong Hwan ; Machova Polakova, Katerina ; Radich, Jerald P. ; Hehlmann, Rüdiger ; Hochhaus, Andreas ; Apperley, Jane F. ; Soverini, Simona</creatorcontrib><description>From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. 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P.</creatorcontrib><creatorcontrib>Ernst, Thomas</creatorcontrib><creatorcontrib>Branford, Susan</creatorcontrib><creatorcontrib>Cayuela, Jean-Michel</creatorcontrib><creatorcontrib>Deininger, Michael</creatorcontrib><creatorcontrib>Fabarius, Alice</creatorcontrib><creatorcontrib>Kim, Dennis Dong Hwan</creatorcontrib><creatorcontrib>Machova Polakova, Katerina</creatorcontrib><creatorcontrib>Radich, Jerald P.</creatorcontrib><creatorcontrib>Hehlmann, Rüdiger</creatorcontrib><creatorcontrib>Hochhaus, Andreas</creatorcontrib><creatorcontrib>Apperley, Jane F.</creatorcontrib><creatorcontrib>Soverini, Simona</creatorcontrib><title>European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. 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P.</au><au>Ernst, Thomas</au><au>Branford, Susan</au><au>Cayuela, Jean-Michel</au><au>Deininger, Michael</au><au>Fabarius, Alice</au><au>Kim, Dennis Dong Hwan</au><au>Machova Polakova, Katerina</au><au>Radich, Jerald P.</au><au>Hehlmann, Rüdiger</au><au>Hochhaus, Andreas</au><au>Apperley, Jane F.</au><au>Soverini, Simona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>37</volume><issue>11</issue><spage>2150</spage><epage>2167</epage><pages>2150-2167</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><abstract>From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. 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| subjects | 45 45/23 45/77 45/91 692/420/755 692/699/1541/1990/2331 Best practice Bone marrow Cancer Cancer Research Chromosomes Chronic myeloid leukemia Critical Care Medicine Cytogenetics Diagnosis Genes Granulocytes Hematology Humans Intensive Internal Medicine Kinases Laboratory methods Laboratory tests Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Medical prognosis Medicine Medicine & Public Health Myeloid leukemia Oncology Protein Kinase Inhibitors Recurrence Remission (Medicine) Review Review Article Testing laboratories |
| title | European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia |
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