Stem cell mutations, associated cancer risk, and consequences for regenerative medicine

Mutation accumulation in stem cells has been associated with cancer risk. However, the presence of numerous mutant clones in healthy tissues has raised the question of what limits cancer initiation. Here, we review recent developments in characterizing mutation accumulation in healthy tissues and co...

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Veröffentlicht in:	Cell stem cell 2023-11, Vol.30 (11), p.1421-1433
Hauptverfasser:	Derks, Lucca L.M., van Boxtel, Ruben
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult carcinogenesis Carcinogenesis - genetics Carcinogenesis - pathology clonal dynamics Humans Mutation - genetics Regenerative Medicine Review somatic mutations stem cell genomics Stem Cells - pathology
Online-Zugang:	Volltext
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