IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis
Infection-related glomerulonephritis (IRGN) is one of the most common causes of acute kidney injury (AKI). Positive glomerular staining of the nephritis-associated plasmin receptor (NAPlr) has been reported as a useful biomarker of IRGN. Although the infection can provoke acute tubulointerstitial ne...
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| Veröffentlicht in: | CEN case reports 2023-11, Vol.12 (4), p.402-407 |
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| creator | Okunaga, Issei Makino, Shin-ichi Honda, Daisuke Tatsumoto, Narihito Aizawa, Masashi Oda, Takashi Asanuma, Katsuhiko |
| description | Infection-related glomerulonephritis (IRGN) is one of the most common causes of acute kidney injury (AKI). Positive glomerular staining of the nephritis-associated plasmin receptor (NAPlr) has been reported as a useful biomarker of IRGN. Although the infection can provoke acute tubulointerstitial nephritis (AIN), there are few reports of positive staining for NAPlr with AIN. We report a case of methicillin-sensitive
Staphylococcus aureus
(MSSA) infection-related nephritis complicated with AIN, which showed positive staining for tubulointerstitial NAPlr. The patient developed AKI and nephrotic syndrome during an intraperitoneal MSSA infection. A diagnosis of IRGN complicated by infection-related acute tubulointerstitial nephritis (IRAIN) was made based on glomerular endocapillary proliferation with tubulointerstitial infiltrating cells and tubular atrophy. Tubulointerstitial infiltrating cells were positive for NAPlr staining and plasmin activity. Treatment of the infection by antibiotics and drainage did not improve the AKI, but steroid administration improved that. NAPlr evaluation is a helpful tool for identifying causes of AIN during infection. |
| doi_str_mv | 10.1007/s13730-023-00782-x |
| format | Article |
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Staphylococcus aureus
(MSSA) infection-related nephritis complicated with AIN, which showed positive staining for tubulointerstitial NAPlr. The patient developed AKI and nephrotic syndrome during an intraperitoneal MSSA infection. A diagnosis of IRGN complicated by infection-related acute tubulointerstitial nephritis (IRAIN) was made based on glomerular endocapillary proliferation with tubulointerstitial infiltrating cells and tubular atrophy. Tubulointerstitial infiltrating cells were positive for NAPlr staining and plasmin activity. Treatment of the infection by antibiotics and drainage did not improve the AKI, but steroid administration improved that. NAPlr evaluation is a helpful tool for identifying causes of AIN during infection.</description><identifier>ISSN: 2192-4449</identifier><identifier>EISSN: 2192-4449</identifier><identifier>DOI: 10.1007/s13730-023-00782-x</identifier><identifier>PMID: 36920749</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Acute Kidney Injury - complications ; Acute Kidney Injury - etiology ; Case Report ; Glomerulonephritis - diagnosis ; Glomerulonephritis, IGA - complications ; Humans ; Immunoglobulin A ; Medicine ; Medicine & Public Health ; Nephritis - complications ; Nephritis, Interstitial - complications ; Nephritis, Interstitial - diagnosis ; Nephritis, Interstitial - drug therapy ; Nephrology ; Staphylococcal Infections - complications ; Staphylococcal Infections - diagnosis ; Staphylococcal Infections - drug therapy ; Urology</subject><ispartof>CEN case reports, 2023-11, Vol.12 (4), p.402-407</ispartof><rights>The Author(s) under exclusive licence to The Japan Society of Nephrology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s) under exclusive licence to The Japan Society of Nephrology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-223a1a8ebf8122dafaa5505bcf090b5ac7c54b829821cef31a076ce8a51025b33</citedby><cites>FETCH-LOGICAL-c403t-223a1a8ebf8122dafaa5505bcf090b5ac7c54b829821cef31a076ce8a51025b33</cites><orcidid>0000-0002-7782-8207</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620344/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620344/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36920749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okunaga, Issei</creatorcontrib><creatorcontrib>Makino, Shin-ichi</creatorcontrib><creatorcontrib>Honda, Daisuke</creatorcontrib><creatorcontrib>Tatsumoto, Narihito</creatorcontrib><creatorcontrib>Aizawa, Masashi</creatorcontrib><creatorcontrib>Oda, Takashi</creatorcontrib><creatorcontrib>Asanuma, Katsuhiko</creatorcontrib><title>IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis</title><title>CEN case reports</title><addtitle>CEN Case Rep</addtitle><addtitle>CEN Case Rep</addtitle><description>Infection-related glomerulonephritis (IRGN) is one of the most common causes of acute kidney injury (AKI). Positive glomerular staining of the nephritis-associated plasmin receptor (NAPlr) has been reported as a useful biomarker of IRGN. Although the infection can provoke acute tubulointerstitial nephritis (AIN), there are few reports of positive staining for NAPlr with AIN. We report a case of methicillin-sensitive
Staphylococcus aureus
(MSSA) infection-related nephritis complicated with AIN, which showed positive staining for tubulointerstitial NAPlr. The patient developed AKI and nephrotic syndrome during an intraperitoneal MSSA infection. A diagnosis of IRGN complicated by infection-related acute tubulointerstitial nephritis (IRAIN) was made based on glomerular endocapillary proliferation with tubulointerstitial infiltrating cells and tubular atrophy. Tubulointerstitial infiltrating cells were positive for NAPlr staining and plasmin activity. Treatment of the infection by antibiotics and drainage did not improve the AKI, but steroid administration improved that. NAPlr evaluation is a helpful tool for identifying causes of AIN during infection.</description><subject>Acute Kidney Injury - complications</subject><subject>Acute Kidney Injury - etiology</subject><subject>Case Report</subject><subject>Glomerulonephritis - diagnosis</subject><subject>Glomerulonephritis, IGA - complications</subject><subject>Humans</subject><subject>Immunoglobulin A</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephritis - complications</subject><subject>Nephritis, Interstitial - complications</subject><subject>Nephritis, Interstitial - diagnosis</subject><subject>Nephritis, Interstitial - drug therapy</subject><subject>Nephrology</subject><subject>Staphylococcal Infections - complications</subject><subject>Staphylococcal Infections - diagnosis</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Urology</subject><issn>2192-4449</issn><issn>2192-4449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9PGzEQxa2qqCDIF-ih2mMvpuM_m909VRGiEAlRDvRseZ3ZxMhrp7YX0m-P20AEl55sz7z3xpofIZ8ZnDOA5ltiohFAgQtani2nuw_khLOOUyll9_HN_ZjMUnoAACYk1NB9Isdi3nFoZHdC-uV6QVdhtF77XFk_oMk2eBrR6Yyrau3CiHFyweN2E222qXqyeVPdLu5cpNuQSukRqzz1RWN9xphyKWlXHQxn5GjQLuHs5Twlv35c3l9c05ufV8uLxQ01EkSmnAvNdIv90DLOV3rQuq6h7s0AHfS1No2pZd_yruXM4CCYhmZusNU1A173QpyS7_vc7dSPuDLoc9RObaMddfyjgrbqfcfbjVqHR8VgzkFIWRK-viTE8HvClNVok0HntMcwJcWbtuFMlEUWKd9LTQwpRRwOcxiov4DUHpAqgNQ_QGpXTF_e_vBgecVRBGIvSKXl1xjVQ5iiL1v7X-wzp4Gf7g</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Okunaga, Issei</creator><creator>Makino, Shin-ichi</creator><creator>Honda, Daisuke</creator><creator>Tatsumoto, Narihito</creator><creator>Aizawa, Masashi</creator><creator>Oda, Takashi</creator><creator>Asanuma, Katsuhiko</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7782-8207</orcidid></search><sort><creationdate>20231101</creationdate><title>IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis</title><author>Okunaga, Issei ; Makino, Shin-ichi ; Honda, Daisuke ; Tatsumoto, Narihito ; Aizawa, Masashi ; Oda, Takashi ; Asanuma, Katsuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-223a1a8ebf8122dafaa5505bcf090b5ac7c54b829821cef31a076ce8a51025b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute Kidney Injury - complications</topic><topic>Acute Kidney Injury - etiology</topic><topic>Case Report</topic><topic>Glomerulonephritis - diagnosis</topic><topic>Glomerulonephritis, IGA - complications</topic><topic>Humans</topic><topic>Immunoglobulin A</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephritis - complications</topic><topic>Nephritis, Interstitial - complications</topic><topic>Nephritis, Interstitial - diagnosis</topic><topic>Nephritis, Interstitial - drug therapy</topic><topic>Nephrology</topic><topic>Staphylococcal Infections - complications</topic><topic>Staphylococcal Infections - diagnosis</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okunaga, Issei</creatorcontrib><creatorcontrib>Makino, Shin-ichi</creatorcontrib><creatorcontrib>Honda, Daisuke</creatorcontrib><creatorcontrib>Tatsumoto, Narihito</creatorcontrib><creatorcontrib>Aizawa, Masashi</creatorcontrib><creatorcontrib>Oda, Takashi</creatorcontrib><creatorcontrib>Asanuma, Katsuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>CEN case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okunaga, Issei</au><au>Makino, Shin-ichi</au><au>Honda, Daisuke</au><au>Tatsumoto, Narihito</au><au>Aizawa, Masashi</au><au>Oda, Takashi</au><au>Asanuma, Katsuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis</atitle><jtitle>CEN case reports</jtitle><stitle>CEN Case Rep</stitle><addtitle>CEN Case Rep</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>12</volume><issue>4</issue><spage>402</spage><epage>407</epage><pages>402-407</pages><issn>2192-4449</issn><eissn>2192-4449</eissn><abstract>Infection-related glomerulonephritis (IRGN) is one of the most common causes of acute kidney injury (AKI). Positive glomerular staining of the nephritis-associated plasmin receptor (NAPlr) has been reported as a useful biomarker of IRGN. Although the infection can provoke acute tubulointerstitial nephritis (AIN), there are few reports of positive staining for NAPlr with AIN. We report a case of methicillin-sensitive
Staphylococcus aureus
(MSSA) infection-related nephritis complicated with AIN, which showed positive staining for tubulointerstitial NAPlr. The patient developed AKI and nephrotic syndrome during an intraperitoneal MSSA infection. A diagnosis of IRGN complicated by infection-related acute tubulointerstitial nephritis (IRAIN) was made based on glomerular endocapillary proliferation with tubulointerstitial infiltrating cells and tubular atrophy. Tubulointerstitial infiltrating cells were positive for NAPlr staining and plasmin activity. Treatment of the infection by antibiotics and drainage did not improve the AKI, but steroid administration improved that. NAPlr evaluation is a helpful tool for identifying causes of AIN during infection.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36920749</pmid><doi>10.1007/s13730-023-00782-x</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7782-8207</orcidid></addata></record> |
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| subjects | Acute Kidney Injury - complications Acute Kidney Injury - etiology Case Report Glomerulonephritis - diagnosis Glomerulonephritis, IGA - complications Humans Immunoglobulin A Medicine Medicine & Public Health Nephritis - complications Nephritis, Interstitial - complications Nephritis, Interstitial - diagnosis Nephritis, Interstitial - drug therapy Nephrology Staphylococcal Infections - complications Staphylococcal Infections - diagnosis Staphylococcal Infections - drug therapy Urology |
| title | IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis |
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