Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function 1 . We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women 2 , selec...
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| Veröffentlicht in: | Nature (London) 2023-11, Vol.623 (7985), p.106-114 |
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| creator | Namburete, Ana I. L. Papież, Bartłomiej W. Fernandes, Michelle Wyburd, Madeleine K. Hesse, Linde S. Moser, Felipe A. Ismail, Leila Cheikh Gunier, Robert B. Squier, Waney Ohuma, Eric O. Carvalho, Maria Jaffer, Yasmin Gravett, Michael Wu, Qingqing Lambert, Ann Winsey, Adele Restrepo-Méndez, María C. Bertino, Enrico Purwar, Manorama Barros, Fernando C. Stein, Alan Noble, J. Alison Molnár, Zoltán Jenkinson, Mark Bhutta, Zulfiqar A. Papageorghiou, Aris T. Villar, José Kennedy, Stephen H. |
| description | Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function
1
. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women
2
, selected using World Health Organization recommendations for growth standards
3
. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2 years of age
4
,
5
. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline
6
–
8
. The atlas corresponds structurally to published magnetic resonance images
9
, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31 weeks’ gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14 weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26 weeks’ gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.
A normative digital atlas of fetal brain maturation produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 fetuses presents a unique spatiotemporal benchmark from a large cohort with normative postnatal growth and neurodevelopment at 2 years of age. |
| doi_str_mv | 10.1038/s41586-023-06630-3 |
| format | Article |
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1
. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women
2
, selected using World Health Organization recommendations for growth standards
3
. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2 years of age
4
,
5
. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline
6
–
8
. The atlas corresponds structurally to published magnetic resonance images
9
, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31 weeks’ gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14 weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26 weeks’ gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.
A normative digital atlas of fetal brain maturation produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 fetuses presents a unique spatiotemporal benchmark from a large cohort with normative postnatal growth and neurodevelopment at 2 years of age.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/s41586-023-06630-3</identifier><identifier>PMID: 37880365</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/378 ; 692/700/1421 ; 692/700/1720/3194 ; Asymmetry ; Bats ; Brain ; Brain - anatomy & histology ; Brain - embryology ; Brain - growth & development ; Cerebral cortex ; Cerebral hemispheres ; Child, Preschool ; Female ; Fetal Development ; Fetus - embryology ; Fetuses ; Gestation ; Gestational Age ; Gray Matter - anatomy & histology ; Gray Matter - embryology ; Gray Matter - growth & development ; Growth patterns ; Healthy Volunteers ; Hemispheric laterality ; Humanities and Social Sciences ; Humans ; Imaging, Three-Dimensional ; Internationality ; Magnetic resonance ; Magnetic Resonance Imaging ; Maturation ; Morphology ; multidisciplinary ; Neurodevelopment ; Organ Size ; Pregnancy ; Prospective Studies ; Science ; Science (multidisciplinary) ; Substantia grisea ; Ultrasonic imaging ; Ultrasonography ; Variability ; World Health Organization</subject><ispartof>Nature (London), 2023-11, Vol.623 (7985), p.106-114</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>Copyright Nature Publishing Group Nov 2, 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-4d7064e628b957dee63be01ea53cba7409790d0181ee0d53a15247fbefd6b4d43</citedby><cites>FETCH-LOGICAL-c475t-4d7064e628b957dee63be01ea53cba7409790d0181ee0d53a15247fbefd6b4d43</cites><orcidid>0000-0003-0637-599X ; 0000-0002-9119-436X ; 0000-0001-8207-2822 ; 0000-0001-6043-0166 ; 0000-0001-8143-2232 ; 0000-0002-0051-3389 ; 0000-0002-6852-6004 ; 0000-0002-3060-3772 ; 0000-0003-0135-9317</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41586-023-06630-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41586-023-06630-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37880365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Namburete, Ana I. L.</creatorcontrib><creatorcontrib>Papież, Bartłomiej W.</creatorcontrib><creatorcontrib>Fernandes, Michelle</creatorcontrib><creatorcontrib>Wyburd, Madeleine K.</creatorcontrib><creatorcontrib>Hesse, Linde S.</creatorcontrib><creatorcontrib>Moser, Felipe A.</creatorcontrib><creatorcontrib>Ismail, Leila Cheikh</creatorcontrib><creatorcontrib>Gunier, Robert B.</creatorcontrib><creatorcontrib>Squier, Waney</creatorcontrib><creatorcontrib>Ohuma, Eric O.</creatorcontrib><creatorcontrib>Carvalho, Maria</creatorcontrib><creatorcontrib>Jaffer, Yasmin</creatorcontrib><creatorcontrib>Gravett, Michael</creatorcontrib><creatorcontrib>Wu, Qingqing</creatorcontrib><creatorcontrib>Lambert, Ann</creatorcontrib><creatorcontrib>Winsey, Adele</creatorcontrib><creatorcontrib>Restrepo-Méndez, María C.</creatorcontrib><creatorcontrib>Bertino, Enrico</creatorcontrib><creatorcontrib>Purwar, Manorama</creatorcontrib><creatorcontrib>Barros, Fernando C.</creatorcontrib><creatorcontrib>Stein, Alan</creatorcontrib><creatorcontrib>Noble, J. Alison</creatorcontrib><creatorcontrib>Molnár, Zoltán</creatorcontrib><creatorcontrib>Jenkinson, Mark</creatorcontrib><creatorcontrib>Bhutta, Zulfiqar A.</creatorcontrib><creatorcontrib>Papageorghiou, Aris T.</creatorcontrib><creatorcontrib>Villar, José</creatorcontrib><creatorcontrib>Kennedy, Stephen H.</creatorcontrib><title>Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function
1
. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women
2
, selected using World Health Organization recommendations for growth standards
3
. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2 years of age
4
,
5
. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline
6
–
8
. The atlas corresponds structurally to published magnetic resonance images
9
, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31 weeks’ gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14 weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26 weeks’ gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.
A normative digital atlas of fetal brain maturation produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 fetuses presents a unique spatiotemporal benchmark from a large cohort with normative postnatal growth and neurodevelopment at 2 years of age.</description><subject>59/57</subject><subject>631/378</subject><subject>692/700/1421</subject><subject>692/700/1720/3194</subject><subject>Asymmetry</subject><subject>Bats</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - embryology</subject><subject>Brain - growth & development</subject><subject>Cerebral cortex</subject><subject>Cerebral hemispheres</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fetal Development</subject><subject>Fetus - embryology</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>Gray Matter - anatomy & histology</subject><subject>Gray Matter - embryology</subject><subject>Gray Matter - growth & development</subject><subject>Growth patterns</subject><subject>Healthy Volunteers</subject><subject>Hemispheric laterality</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Internationality</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Maturation</subject><subject>Morphology</subject><subject>multidisciplinary</subject><subject>Neurodevelopment</subject><subject>Organ Size</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Substantia grisea</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Variability</subject><subject>World Health Organization</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9P3DAQxa0KVBbaL9ADssSll9Dxn9jeE0KI0kqoXEDqzXKSCQQlcbCdRfvt8bKUlh64eCy937yZ0SPkC4NjBsJ8i5KVRhXARQFKCSjEB7JgUqtCKqN3yAKAmwKMUHtkP8Z7ACiZlh_JntDGgFDlgvz-5cPgUrdCGqdcfcJh8sH1tMWU3yq4bqSZmMNGHeljl-5ozP_Yujr5sKYNrrD304Bjoi5RTtfoQvxEdlvXR_z8Ug_Izffz67MfxeXVxc-z08uilrpMhWw0KImKm2pZ6gZRiQqBoStFXTktYamX0AAzDBGaUjhWcqnbCttGVbKR4oCcbH2nuRqwqfMWeXs7hW5wYW296-xbZezu7K1fWQaKAxiTHb6-OAT_MGNMduhijX3vRvRztNwYLrhgapnRo__Qez-HMd-3oRRoowVkim-pOvgYA7av2zCwm-TsNjmbk7PPyVmRmw7_veO15U9UGRBbIGZpvMXwd_Y7tk_vXaX3</recordid><startdate>20231102</startdate><enddate>20231102</enddate><creator>Namburete, Ana I. 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L. ; Papież, Bartłomiej W. ; Fernandes, Michelle ; Wyburd, Madeleine K. ; Hesse, Linde S. ; Moser, Felipe A. ; Ismail, Leila Cheikh ; Gunier, Robert B. ; Squier, Waney ; Ohuma, Eric O. ; Carvalho, Maria ; Jaffer, Yasmin ; Gravett, Michael ; Wu, Qingqing ; Lambert, Ann ; Winsey, Adele ; Restrepo-Méndez, María C. ; Bertino, Enrico ; Purwar, Manorama ; Barros, Fernando C. ; Stein, Alan ; Noble, J. Alison ; Molnár, Zoltán ; Jenkinson, Mark ; Bhutta, Zulfiqar A. ; Papageorghiou, Aris T. ; Villar, José ; Kennedy, Stephen H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-4d7064e628b957dee63be01ea53cba7409790d0181ee0d53a15247fbefd6b4d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>59/57</topic><topic>631/378</topic><topic>692/700/1421</topic><topic>692/700/1720/3194</topic><topic>Asymmetry</topic><topic>Bats</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain - embryology</topic><topic>Brain - growth & development</topic><topic>Cerebral cortex</topic><topic>Cerebral hemispheres</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fetal Development</topic><topic>Fetus - embryology</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Gestational Age</topic><topic>Gray Matter - anatomy & histology</topic><topic>Gray Matter - embryology</topic><topic>Gray Matter - growth & development</topic><topic>Growth patterns</topic><topic>Healthy Volunteers</topic><topic>Hemispheric laterality</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Internationality</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Maturation</topic><topic>Morphology</topic><topic>multidisciplinary</topic><topic>Neurodevelopment</topic><topic>Organ Size</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Substantia grisea</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Variability</topic><topic>World Health Organization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Namburete, Ana I. L.</creatorcontrib><creatorcontrib>Papież, Bartłomiej W.</creatorcontrib><creatorcontrib>Fernandes, Michelle</creatorcontrib><creatorcontrib>Wyburd, Madeleine K.</creatorcontrib><creatorcontrib>Hesse, Linde S.</creatorcontrib><creatorcontrib>Moser, Felipe A.</creatorcontrib><creatorcontrib>Ismail, Leila Cheikh</creatorcontrib><creatorcontrib>Gunier, Robert B.</creatorcontrib><creatorcontrib>Squier, Waney</creatorcontrib><creatorcontrib>Ohuma, Eric O.</creatorcontrib><creatorcontrib>Carvalho, Maria</creatorcontrib><creatorcontrib>Jaffer, Yasmin</creatorcontrib><creatorcontrib>Gravett, Michael</creatorcontrib><creatorcontrib>Wu, Qingqing</creatorcontrib><creatorcontrib>Lambert, Ann</creatorcontrib><creatorcontrib>Winsey, Adele</creatorcontrib><creatorcontrib>Restrepo-Méndez, María C.</creatorcontrib><creatorcontrib>Bertino, Enrico</creatorcontrib><creatorcontrib>Purwar, Manorama</creatorcontrib><creatorcontrib>Barros, Fernando C.</creatorcontrib><creatorcontrib>Stein, Alan</creatorcontrib><creatorcontrib>Noble, J. Alison</creatorcontrib><creatorcontrib>Molnár, Zoltán</creatorcontrib><creatorcontrib>Jenkinson, Mark</creatorcontrib><creatorcontrib>Bhutta, Zulfiqar A.</creatorcontrib><creatorcontrib>Papageorghiou, Aris T.</creatorcontrib><creatorcontrib>Villar, José</creatorcontrib><creatorcontrib>Kennedy, Stephen H.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Namburete, Ana I. L.</au><au>Papież, Bartłomiej W.</au><au>Fernandes, Michelle</au><au>Wyburd, Madeleine K.</au><au>Hesse, Linde S.</au><au>Moser, Felipe A.</au><au>Ismail, Leila Cheikh</au><au>Gunier, Robert B.</au><au>Squier, Waney</au><au>Ohuma, Eric O.</au><au>Carvalho, Maria</au><au>Jaffer, Yasmin</au><au>Gravett, Michael</au><au>Wu, Qingqing</au><au>Lambert, Ann</au><au>Winsey, Adele</au><au>Restrepo-Méndez, María C.</au><au>Bertino, Enrico</au><au>Purwar, Manorama</au><au>Barros, Fernando C.</au><au>Stein, Alan</au><au>Noble, J. Alison</au><au>Molnár, Zoltán</au><au>Jenkinson, Mark</au><au>Bhutta, Zulfiqar A.</au><au>Papageorghiou, Aris T.</au><au>Villar, José</au><au>Kennedy, Stephen H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2023-11-02</date><risdate>2023</risdate><volume>623</volume><issue>7985</issue><spage>106</spage><epage>114</epage><pages>106-114</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function
1
. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women
2
, selected using World Health Organization recommendations for growth standards
3
. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2 years of age
4
,
5
. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline
6
–
8
. The atlas corresponds structurally to published magnetic resonance images
9
, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31 weeks’ gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14 weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26 weeks’ gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.
A normative digital atlas of fetal brain maturation produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 fetuses presents a unique spatiotemporal benchmark from a large cohort with normative postnatal growth and neurodevelopment at 2 years of age.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37880365</pmid><doi>10.1038/s41586-023-06630-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0637-599X</orcidid><orcidid>https://orcid.org/0000-0002-9119-436X</orcidid><orcidid>https://orcid.org/0000-0001-8207-2822</orcidid><orcidid>https://orcid.org/0000-0001-6043-0166</orcidid><orcidid>https://orcid.org/0000-0001-8143-2232</orcidid><orcidid>https://orcid.org/0000-0002-0051-3389</orcidid><orcidid>https://orcid.org/0000-0002-6852-6004</orcidid><orcidid>https://orcid.org/0000-0002-3060-3772</orcidid><orcidid>https://orcid.org/0000-0003-0135-9317</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 2023-11, Vol.623 (7985), p.106-114 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10620088 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 59/57 631/378 692/700/1421 692/700/1720/3194 Asymmetry Bats Brain Brain - anatomy & histology Brain - embryology Brain - growth & development Cerebral cortex Cerebral hemispheres Child, Preschool Female Fetal Development Fetus - embryology Fetuses Gestation Gestational Age Gray Matter - anatomy & histology Gray Matter - embryology Gray Matter - growth & development Growth patterns Healthy Volunteers Hemispheric laterality Humanities and Social Sciences Humans Imaging, Three-Dimensional Internationality Magnetic resonance Magnetic Resonance Imaging Maturation Morphology multidisciplinary Neurodevelopment Organ Size Pregnancy Prospective Studies Science Science (multidisciplinary) Substantia grisea Ultrasonic imaging Ultrasonography Variability World Health Organization |
| title | Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T14%3A23%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Normative%20spatiotemporal%20fetal%20brain%20maturation%20with%20satisfactory%20development%20at%202%20years&rft.jtitle=Nature%20(London)&rft.au=Namburete,%20Ana%20I.%20L.&rft.date=2023-11-02&rft.volume=623&rft.issue=7985&rft.spage=106&rft.epage=114&rft.pages=106-114&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/s41586-023-06630-3&rft_dat=%3Cproquest_pubme%3E2882323169%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2886078730&rft_id=info:pmid/37880365&rfr_iscdi=true |