Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice
Background. Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess b...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2023-01, Vol.2023 (1), p.4559802-4559802 |
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| creator | Liu, Lei Lin, Chen Li, Xiu Cheng, Yulan Wang, Rui Luo, Chao Zhao, Xinyuan Jiang, Zhitao |
| description | Background. Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess beneficial effects to attenuate inflammation. Here, we explored the potential protective effects and underlying mechanisms of alkaline mineral water against calcium oxalate-induced kidney injury. Methods. We performed the mice kidney stone model by administering glyoxylate at 100 mg/kg once daily for 7 days. To assess the effects of alkaline mineral water on oxalate-induced kidney injury, mice drank different water (distilled water, natural mineral water at pH = 8.0, as well as natural mineral water at pH = 9.3) for 7 days, respectively, followed by glyoxylate exposure. After collection, crystal formation, kidney injury and cell apoptosis, fibrosis, oxidative stress, as well as inflammation were measured. Results. Our results showed that glyoxylate treatment led to kidney crystal formation and fibrosis, which can be attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury and cell apoptosis, oxidative stress, and inflammation. Conclusion. Alkaline mineral water supplement prevents progression of glyoxylate-induced kidney stones through alleviating oxidative stress and inflammation. |
| doi_str_mv | 10.1155/2023/4559802 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10620026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2886121862</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2282-e1bf016d9b5ce8064fa39a9eacb6fa1c85e0728f8a62587a364ac7b13320a7e03</originalsourceid><addsrcrecordid>eNp9kU9P3DAQxaMKpPKnt34AS1wq0bC2k9jOCaEVhRUgemjVHipZE2dcvGRtcJKF_fZ42RVSOfRij8Y_P72Zl2WfGT1hrKomnPJiUlZVrSj_kO0xWbK85ErtvNXy98dsv-_nlPJaSrmX_fkew4BmcEsk59amigRLzrp76JxHcpOOCB35BQNGEjyZQmfcuCC3z9ClXj7z7WiwJVeu9bgiMz8f44o4n34aPMx2LXQ9ftreB9nPb-c_ppf59e3FbHp2nRvOFc-RNZYy0dZNZVBRUVooaqgRTCMsMKMqpJIrq0DwSkkoRAlGNqwoOAWJtDjITje6D2OzwNagH5Jp_RDdAuJKB3D63xfv7vTfsNSMCp5WIZLCl61CDI8j9oNeuN5g14HHMPY6LVEUXBaSJ_ToHToPY_RpvleKcabEmvq6oUwMfR_RvrlhVK_D0uuw9DashB9v8DvnW3hy_6dfABQBk9M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2886121862</pqid></control><display><type>article</type><title>Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice</title><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Lei ; Lin, Chen ; Li, Xiu ; Cheng, Yulan ; Wang, Rui ; Luo, Chao ; Zhao, Xinyuan ; Jiang, Zhitao</creator><contributor>Di Giacomo, Claudia ; Claudia Di Giacomo</contributor><creatorcontrib>Liu, Lei ; Lin, Chen ; Li, Xiu ; Cheng, Yulan ; Wang, Rui ; Luo, Chao ; Zhao, Xinyuan ; Jiang, Zhitao ; Di Giacomo, Claudia ; Claudia Di Giacomo</creatorcontrib><description>Background. Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess beneficial effects to attenuate inflammation. Here, we explored the potential protective effects and underlying mechanisms of alkaline mineral water against calcium oxalate-induced kidney injury. Methods. We performed the mice kidney stone model by administering glyoxylate at 100 mg/kg once daily for 7 days. To assess the effects of alkaline mineral water on oxalate-induced kidney injury, mice drank different water (distilled water, natural mineral water at pH = 8.0, as well as natural mineral water at pH = 9.3) for 7 days, respectively, followed by glyoxylate exposure. After collection, crystal formation, kidney injury and cell apoptosis, fibrosis, oxidative stress, as well as inflammation were measured. Results. Our results showed that glyoxylate treatment led to kidney crystal formation and fibrosis, which can be attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury and cell apoptosis, oxidative stress, and inflammation. Conclusion. Alkaline mineral water supplement prevents progression of glyoxylate-induced kidney stones through alleviating oxidative stress and inflammation.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2023/4559802</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Antibodies ; Apoptosis ; Calcium oxalate ; Calculi ; Cell injury ; Crystals ; Drinking water ; Epithelial cells ; Fibrosis ; Inflammation ; Kidney stones ; Kidneys ; Laboratory animals ; Lithiasis ; Mineral water ; Nephrolithiasis ; Oxalic acid ; Oxidative stress ; Polymerase chain reaction ; Renal insufficiency ; Uric acid ; Variance analysis</subject><ispartof>Evidence-based complementary and alternative medicine, 2023-01, Vol.2023 (1), p.4559802-4559802</ispartof><rights>Copyright © 2023 Lei Liu et al.</rights><rights>Copyright © 2023 Lei Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2023 Lei Liu et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2282-e1bf016d9b5ce8064fa39a9eacb6fa1c85e0728f8a62587a364ac7b13320a7e03</cites><orcidid>0000-0002-3294-6832 ; 0009-0004-5154-067X ; 0009-0005-2525-1337 ; 0000-0003-2084-1133 ; 0000-0002-6490-5568 ; 0009-0005-9438-3181 ; 0000-0002-7317-8016 ; 0000-0002-3932-3574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620026/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620026/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids></links><search><contributor>Di Giacomo, Claudia</contributor><contributor>Claudia Di Giacomo</contributor><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Lin, Chen</creatorcontrib><creatorcontrib>Li, Xiu</creatorcontrib><creatorcontrib>Cheng, Yulan</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Luo, Chao</creatorcontrib><creatorcontrib>Zhao, Xinyuan</creatorcontrib><creatorcontrib>Jiang, Zhitao</creatorcontrib><title>Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice</title><title>Evidence-based complementary and alternative medicine</title><description>Background. Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess beneficial effects to attenuate inflammation. Here, we explored the potential protective effects and underlying mechanisms of alkaline mineral water against calcium oxalate-induced kidney injury. Methods. We performed the mice kidney stone model by administering glyoxylate at 100 mg/kg once daily for 7 days. To assess the effects of alkaline mineral water on oxalate-induced kidney injury, mice drank different water (distilled water, natural mineral water at pH = 8.0, as well as natural mineral water at pH = 9.3) for 7 days, respectively, followed by glyoxylate exposure. After collection, crystal formation, kidney injury and cell apoptosis, fibrosis, oxidative stress, as well as inflammation were measured. Results. Our results showed that glyoxylate treatment led to kidney crystal formation and fibrosis, which can be attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury and cell apoptosis, oxidative stress, and inflammation. Conclusion. Alkaline mineral water supplement prevents progression of glyoxylate-induced kidney stones through alleviating oxidative stress and inflammation.</description><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Calcium oxalate</subject><subject>Calculi</subject><subject>Cell injury</subject><subject>Crystals</subject><subject>Drinking water</subject><subject>Epithelial cells</subject><subject>Fibrosis</subject><subject>Inflammation</subject><subject>Kidney stones</subject><subject>Kidneys</subject><subject>Laboratory animals</subject><subject>Lithiasis</subject><subject>Mineral water</subject><subject>Nephrolithiasis</subject><subject>Oxalic acid</subject><subject>Oxidative stress</subject><subject>Polymerase chain reaction</subject><subject>Renal insufficiency</subject><subject>Uric acid</subject><subject>Variance analysis</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9P3DAQxaMKpPKnt34AS1wq0bC2k9jOCaEVhRUgemjVHipZE2dcvGRtcJKF_fZ42RVSOfRij8Y_P72Zl2WfGT1hrKomnPJiUlZVrSj_kO0xWbK85ErtvNXy98dsv-_nlPJaSrmX_fkew4BmcEsk59amigRLzrp76JxHcpOOCB35BQNGEjyZQmfcuCC3z9ClXj7z7WiwJVeu9bgiMz8f44o4n34aPMx2LXQ9ftreB9nPb-c_ppf59e3FbHp2nRvOFc-RNZYy0dZNZVBRUVooaqgRTCMsMKMqpJIrq0DwSkkoRAlGNqwoOAWJtDjITje6D2OzwNagH5Jp_RDdAuJKB3D63xfv7vTfsNSMCp5WIZLCl61CDI8j9oNeuN5g14HHMPY6LVEUXBaSJ_ToHToPY_RpvleKcabEmvq6oUwMfR_RvrlhVK_D0uuw9DashB9v8DvnW3hy_6dfABQBk9M</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Liu, Lei</creator><creator>Lin, Chen</creator><creator>Li, Xiu</creator><creator>Cheng, Yulan</creator><creator>Wang, Rui</creator><creator>Luo, Chao</creator><creator>Zhao, Xinyuan</creator><creator>Jiang, Zhitao</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3294-6832</orcidid><orcidid>https://orcid.org/0009-0004-5154-067X</orcidid><orcidid>https://orcid.org/0009-0005-2525-1337</orcidid><orcidid>https://orcid.org/0000-0003-2084-1133</orcidid><orcidid>https://orcid.org/0000-0002-6490-5568</orcidid><orcidid>https://orcid.org/0009-0005-9438-3181</orcidid><orcidid>https://orcid.org/0000-0002-7317-8016</orcidid><orcidid>https://orcid.org/0000-0002-3932-3574</orcidid></search><sort><creationdate>20230101</creationdate><title>Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice</title><author>Liu, Lei ; Lin, Chen ; Li, Xiu ; Cheng, Yulan ; Wang, Rui ; Luo, Chao ; Zhao, Xinyuan ; Jiang, Zhitao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2282-e1bf016d9b5ce8064fa39a9eacb6fa1c85e0728f8a62587a364ac7b13320a7e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Calcium oxalate</topic><topic>Calculi</topic><topic>Cell injury</topic><topic>Crystals</topic><topic>Drinking water</topic><topic>Epithelial cells</topic><topic>Fibrosis</topic><topic>Inflammation</topic><topic>Kidney stones</topic><topic>Kidneys</topic><topic>Laboratory animals</topic><topic>Lithiasis</topic><topic>Mineral water</topic><topic>Nephrolithiasis</topic><topic>Oxalic acid</topic><topic>Oxidative stress</topic><topic>Polymerase chain reaction</topic><topic>Renal insufficiency</topic><topic>Uric acid</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Lin, Chen</creatorcontrib><creatorcontrib>Li, Xiu</creatorcontrib><creatorcontrib>Cheng, Yulan</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Luo, Chao</creatorcontrib><creatorcontrib>Zhao, Xinyuan</creatorcontrib><creatorcontrib>Jiang, Zhitao</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lei</au><au>Lin, Chen</au><au>Li, Xiu</au><au>Cheng, Yulan</au><au>Wang, Rui</au><au>Luo, Chao</au><au>Zhao, Xinyuan</au><au>Jiang, Zhitao</au><au>Di Giacomo, Claudia</au><au>Claudia Di Giacomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2023-01-01</date><risdate>2023</risdate><volume>2023</volume><issue>1</issue><spage>4559802</spage><epage>4559802</epage><pages>4559802-4559802</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess beneficial effects to attenuate inflammation. Here, we explored the potential protective effects and underlying mechanisms of alkaline mineral water against calcium oxalate-induced kidney injury. Methods. We performed the mice kidney stone model by administering glyoxylate at 100 mg/kg once daily for 7 days. To assess the effects of alkaline mineral water on oxalate-induced kidney injury, mice drank different water (distilled water, natural mineral water at pH = 8.0, as well as natural mineral water at pH = 9.3) for 7 days, respectively, followed by glyoxylate exposure. After collection, crystal formation, kidney injury and cell apoptosis, fibrosis, oxidative stress, as well as inflammation were measured. Results. Our results showed that glyoxylate treatment led to kidney crystal formation and fibrosis, which can be attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury and cell apoptosis, oxidative stress, and inflammation. Conclusion. Alkaline mineral water supplement prevents progression of glyoxylate-induced kidney stones through alleviating oxidative stress and inflammation.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2023/4559802</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3294-6832</orcidid><orcidid>https://orcid.org/0009-0004-5154-067X</orcidid><orcidid>https://orcid.org/0009-0005-2525-1337</orcidid><orcidid>https://orcid.org/0000-0003-2084-1133</orcidid><orcidid>https://orcid.org/0000-0002-6490-5568</orcidid><orcidid>https://orcid.org/0009-0005-9438-3181</orcidid><orcidid>https://orcid.org/0000-0002-7317-8016</orcidid><orcidid>https://orcid.org/0000-0002-3932-3574</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Apoptosis Calcium oxalate Calculi Cell injury Crystals Drinking water Epithelial cells Fibrosis Inflammation Kidney stones Kidneys Laboratory animals Lithiasis Mineral water Nephrolithiasis Oxalic acid Oxidative stress Polymerase chain reaction Renal insufficiency Uric acid Variance analysis |
| title | Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice |
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