Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors

The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74 -/- mice showed autism- and anxiety-like behaviors along with increased excitability of pyramidal neurons (PNs) in the prelimbic cortex (PL), which were reversed by Tmem...

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Veröffentlicht in:	Molecular psychiatry 2023-06, Vol.28 (6), p.2343-2354
Hauptverfasser:	Luo, Yi-Fan, Lu, Lu, Song, Heng-Yi, Xu, Han, Zheng, Zhi-Wei, Wu, Zhou-Yue, Jiang, Chen-Chen, Tong, Chu, Yuan, Hao-Yang, Liu, Xiu-Xiu, Chen, Xiang, Sun, Mei-ling, Tang, Ya-Min, Fan, Heng-Yu, Han, Feng, Lu, Ying-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 631/154 631/378 64/60 9/74 Animals Anxiety Autism Autism Spectrum Disorder - genetics Autistic Disorder - genetics Basolateral Nuclear Complex Behavioral Sciences Biological Psychology Caudate-putamen Cerebral Cortex Comorbidity Drug development Excitability Hyperactivity Interneurons Medicine Medicine & Public Health Mice Neostriatum Neurosciences Pharmacotherapy Prefrontal Cortex Psychiatry Pyramidal cells
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