Development of Chitosan/Sodium Carboxymethylcellulose Complexes to Improve the Simvastatin Release Rate: Polymer/Polymer and Drug/Polymer Interactions’ Effects on Kinetic Models

Simvastatin (SIM) is a potent lipid-lowering drug used to control hyper-cholesterolemia and prevent cardiovascular diseases. SIM presents low oral bioavailability (5%) because of its low aqueous solubility. In this work, polyelectrolyte complexes (PEC) are developed with different chitosan (CS) and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Polymers 2023-10, Vol.15 (20), p.4184
Hauptverfasser:	López-Manzanara Pérez, Celia, Torres-Pabón, Norma Sofía, Laguna, Almudena, Torrado, Guillermo, de la Torre-Iglesias, Paloma M, Torrado-Santiago, Santiago, Torrado-Salmerón, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia Analysis Bioavailability Carboxymethyl cellulose Carboxymethylcellulose Cardiovascular disease Chemical processes Chemical reaction, Rate of Chitin Chitosan Coordination compounds Dissolution Drug dosages Electron microscopes Fourier transforms Hydrogels Hydrogen bonds Hyperlipidemia Identification and classification Ionic interactions Kinetics Lipids Methods Nanoparticles Pharmaceuticals Polyelectrolytes Polymers Properties Ratios Raw materials Scanning electron microscopy Simvastatin Sodium Spectrum analysis Structure X ray powder diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!