Celecoxib Suppresses NF-κB p65 (RelA) and TNFα Expression Signaling in Glioblastoma

Background: Glioblastoma (GBM) harbors significant genetic heterogeneity, high infiltrative capacity, and patterns of relapse following many therapies. The expression of nuclear factor kappa-B (NF-κB p65 (RelA)) and signaling pathways is constitutively activated in GBM through inflammatory stimulati...

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Veröffentlicht in:	Journal of clinical medicine 2023-10, Vol.12 (20), p.6683
Hauptverfasser:	Ahsan, Hina, Malik, Shaukat Iqbal, Shah, Fawad Ali, El-Serehy, Hamed A, Ullah, Amin, Shah, Zafar Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain cancer Brain research Cancer Cancer therapies Celecoxib Cellular signal transduction Chemotherapy Clinical medicine Datasets Drug therapy Gene expression Genetic aspects Genomes Glioblastoma multiforme Health aspects Inflammation Medical prognosis Nonsteroidal anti-inflammatory drugs Oncology, Experimental Radiation Survival analysis Testing Transcription factors Tumor necrosis factor Tumor necrosis factor-TNF Tumors
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