The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features
This retrospective cohort study aimed to explore the association between advanced maternal age and the clinical manifestations as well as laboratory parameters of preeclampsia with severe features. This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinic...
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| Veröffentlicht in: | Journal of clinical medicine 2023-10, Vol.12 (20), p.6545 |
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| creator | Gilboa, Itamar Kupferminc, Michael Schwartz, Anat Landsberg Ashereh, Yisca Yogev, Yariv Rappaport Skornik, Avital Klieger, Chagit Hiersch, Liran Rimon, Eli |
| description | This retrospective cohort study aimed to explore the association between advanced maternal age and the clinical manifestations as well as laboratory parameters of preeclampsia with severe features. This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinical and laboratorial characteristics of patients with preeclampsia with severe features aged ≥40 years old (study group) were compared to those of patients aged |
| doi_str_mv | 10.3390/jcm12206545 |
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This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinical and laboratorial characteristics of patients with preeclampsia with severe features aged ≥40 years old (study group) were compared to those of patients aged <40 years old (control group). Multivariant analysis was applied to assess the association between advanced maternal age and the manifestations of preeclampsia with severe features, adjusting for the variables that exhibited significant differences between the study and control groups. The multivariate analysis revealed that a maternal age of ≥40 years old was an independent risk factor for acute kidney injury (OR = 2.5, CI = 1.2–4.9, p = 0.011) and for new-onset postpartum preeclampsia (OR = 2.4, CI = 1.0–5.6, p = 0.046). Conversely, a maternal age ≥ 40 years old was associated with a reduced risk of HELLP syndrome (OR = 0.4, CI = 0.2–0.9, p = 0.018) and thrombocytopenia (OR = 0.5, CI = 0.3–0.9, p = 0.016) compared to that of the patients < 40 years of age. In conclusion, this study demonstrates that maternal age is significantly associated with the clinical manifestations and laboratory parameters of preeclampsia with severe features, highlighting the importance of age-specific management.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12206545</identifier><identifier>PMID: 37892683</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age factors in disease ; Analysis ; Birth weight ; Blood platelets ; Blood pressure ; Care and treatment ; Clinical medicine ; Creatinine ; Diagnosis ; Edema ; Enzymes ; Gestational age ; Gestational diabetes ; Health aspects ; Laboratories ; Obstetrics ; Preeclampsia ; Regression analysis ; Reproductive technology ; Respiratory distress syndrome ; Risk factors ; Thrombocytopenia ; Variables</subject><ispartof>Journal of clinical medicine, 2023-10, Vol.12 (20), p.6545</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c412t-147ab1c89a7097ed04a51d5b64a001eddfe701bb7a8cfba05b8b81391a78adbb3</cites><orcidid>0000-0002-0941-2074 ; 0000-0003-4443-388X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607653/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607653/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Gilboa, Itamar</creatorcontrib><creatorcontrib>Kupferminc, Michael</creatorcontrib><creatorcontrib>Schwartz, Anat</creatorcontrib><creatorcontrib>Landsberg Ashereh, Yisca</creatorcontrib><creatorcontrib>Yogev, Yariv</creatorcontrib><creatorcontrib>Rappaport Skornik, Avital</creatorcontrib><creatorcontrib>Klieger, Chagit</creatorcontrib><creatorcontrib>Hiersch, Liran</creatorcontrib><creatorcontrib>Rimon, Eli</creatorcontrib><title>The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features</title><title>Journal of clinical medicine</title><description>This retrospective cohort study aimed to explore the association between advanced maternal age and the clinical manifestations as well as laboratory parameters of preeclampsia with severe features. This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinical and laboratorial characteristics of patients with preeclampsia with severe features aged ≥40 years old (study group) were compared to those of patients aged <40 years old (control group). Multivariant analysis was applied to assess the association between advanced maternal age and the manifestations of preeclampsia with severe features, adjusting for the variables that exhibited significant differences between the study and control groups. The multivariate analysis revealed that a maternal age of ≥40 years old was an independent risk factor for acute kidney injury (OR = 2.5, CI = 1.2–4.9, p = 0.011) and for new-onset postpartum preeclampsia (OR = 2.4, CI = 1.0–5.6, p = 0.046). Conversely, a maternal age ≥ 40 years old was associated with a reduced risk of HELLP syndrome (OR = 0.4, CI = 0.2–0.9, p = 0.018) and thrombocytopenia (OR = 0.5, CI = 0.3–0.9, p = 0.016) compared to that of the patients < 40 years of age. In conclusion, this study demonstrates that maternal age is significantly associated with the clinical manifestations and laboratory parameters of preeclampsia with severe features, highlighting the importance of age-specific management.</description><subject>Age factors in disease</subject><subject>Analysis</subject><subject>Birth weight</subject><subject>Blood platelets</subject><subject>Blood pressure</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Creatinine</subject><subject>Diagnosis</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Gestational age</subject><subject>Gestational diabetes</subject><subject>Health aspects</subject><subject>Laboratories</subject><subject>Obstetrics</subject><subject>Preeclampsia</subject><subject>Regression analysis</subject><subject>Reproductive technology</subject><subject>Respiratory distress syndrome</subject><subject>Risk factors</subject><subject>Thrombocytopenia</subject><subject>Variables</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkt9rFDEQxxdRbKl98h8I-CLItfmx2WSfZClWhRYF63OYJLN3OXaTM9m94n_vXltsK2YeMiSf7zfMZKrqLaNnQrT0fOtGxjltZC1fVMecKrWiQouXT_Kj6rSULV2W1jVn6nV1JJRueaPFcRVuNki6UpILMIUUicXpFjGSzu8hOvTkGibMEQbSrZFA9GRaFNcQQ49lutMUknryPSO6AcZdCUBuw7QhP3CPGcklwjRnLG-qVz0MBU8f9pPq5-Wnm4svq6tvn79edFcrVzM-rVitwDKnW1C0VehpDZJ5aZsaKGXofY-KMmsVaNdboNJqq5loGSgN3lpxUn28993NdkTvME4ZBrPLYYT82yQI5vlNDBuzTnvDaENVI8Xi8P7BIadf81KlGUNxOAwQMc3FcK2FVFJIuqDv_kG3aT50647iUreUqUdqDQOaEPu0POwOpqZT6vB7lNcLdfYfagmPY3ApYh-W82eCD_cCl1MpGfu_RTJqDtNhnkyH-AMTS6sI</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Gilboa, Itamar</creator><creator>Kupferminc, Michael</creator><creator>Schwartz, Anat</creator><creator>Landsberg Ashereh, Yisca</creator><creator>Yogev, Yariv</creator><creator>Rappaport Skornik, Avital</creator><creator>Klieger, Chagit</creator><creator>Hiersch, Liran</creator><creator>Rimon, Eli</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0941-2074</orcidid><orcidid>https://orcid.org/0000-0003-4443-388X</orcidid></search><sort><creationdate>20231001</creationdate><title>The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features</title><author>Gilboa, Itamar ; Kupferminc, Michael ; Schwartz, Anat ; Landsberg Ashereh, Yisca ; Yogev, Yariv ; Rappaport Skornik, Avital ; Klieger, Chagit ; Hiersch, Liran ; Rimon, Eli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-147ab1c89a7097ed04a51d5b64a001eddfe701bb7a8cfba05b8b81391a78adbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age factors in disease</topic><topic>Analysis</topic><topic>Birth weight</topic><topic>Blood platelets</topic><topic>Blood pressure</topic><topic>Care and treatment</topic><topic>Clinical medicine</topic><topic>Creatinine</topic><topic>Diagnosis</topic><topic>Edema</topic><topic>Enzymes</topic><topic>Gestational age</topic><topic>Gestational diabetes</topic><topic>Health aspects</topic><topic>Laboratories</topic><topic>Obstetrics</topic><topic>Preeclampsia</topic><topic>Regression analysis</topic><topic>Reproductive technology</topic><topic>Respiratory distress syndrome</topic><topic>Risk factors</topic><topic>Thrombocytopenia</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilboa, Itamar</creatorcontrib><creatorcontrib>Kupferminc, Michael</creatorcontrib><creatorcontrib>Schwartz, Anat</creatorcontrib><creatorcontrib>Landsberg Ashereh, Yisca</creatorcontrib><creatorcontrib>Yogev, Yariv</creatorcontrib><creatorcontrib>Rappaport Skornik, Avital</creatorcontrib><creatorcontrib>Klieger, Chagit</creatorcontrib><creatorcontrib>Hiersch, Liran</creatorcontrib><creatorcontrib>Rimon, Eli</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilboa, Itamar</au><au>Kupferminc, Michael</au><au>Schwartz, Anat</au><au>Landsberg Ashereh, Yisca</au><au>Yogev, Yariv</au><au>Rappaport Skornik, Avital</au><au>Klieger, Chagit</au><au>Hiersch, Liran</au><au>Rimon, Eli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features</atitle><jtitle>Journal of clinical medicine</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>12</volume><issue>20</issue><spage>6545</spage><pages>6545-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>This retrospective cohort study aimed to explore the association between advanced maternal age and the clinical manifestations as well as laboratory parameters of preeclampsia with severe features. This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinical and laboratorial characteristics of patients with preeclampsia with severe features aged ≥40 years old (study group) were compared to those of patients aged <40 years old (control group). Multivariant analysis was applied to assess the association between advanced maternal age and the manifestations of preeclampsia with severe features, adjusting for the variables that exhibited significant differences between the study and control groups. The multivariate analysis revealed that a maternal age of ≥40 years old was an independent risk factor for acute kidney injury (OR = 2.5, CI = 1.2–4.9, p = 0.011) and for new-onset postpartum preeclampsia (OR = 2.4, CI = 1.0–5.6, p = 0.046). Conversely, a maternal age ≥ 40 years old was associated with a reduced risk of HELLP syndrome (OR = 0.4, CI = 0.2–0.9, p = 0.018) and thrombocytopenia (OR = 0.5, CI = 0.3–0.9, p = 0.016) compared to that of the patients < 40 years of age. In conclusion, this study demonstrates that maternal age is significantly associated with the clinical manifestations and laboratory parameters of preeclampsia with severe features, highlighting the importance of age-specific management.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>37892683</pmid><doi>10.3390/jcm12206545</doi><orcidid>https://orcid.org/0000-0002-0941-2074</orcidid><orcidid>https://orcid.org/0000-0003-4443-388X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Age factors in disease Analysis Birth weight Blood platelets Blood pressure Care and treatment Clinical medicine Creatinine Diagnosis Edema Enzymes Gestational age Gestational diabetes Health aspects Laboratories Obstetrics Preeclampsia Regression analysis Reproductive technology Respiratory distress syndrome Risk factors Thrombocytopenia Variables |
| title | The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features |
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