Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis
Subarachnoid Hemorrhage (SAH) is one of the acute neurological conditions that is associated with high mortality and recovery failure rates. In recent years, due to the development of endovascular and classical techniques, the mortality rate after SAH has decreased. Currently, more research is focus...
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Veröffentlicht in: | Journal of clinical medicine 2023-10, Vol.12 (20), p.6638 |
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description | Subarachnoid Hemorrhage (SAH) is one of the acute neurological conditions that is associated with high mortality and recovery failure rates. In recent years, due to the development of endovascular and classical techniques, the mortality rate after SAH has decreased. Currently, more research is focused on understanding the molecular mechanisms underlying SAH. Methods of treatment are investigated in order to obtain the best treatment result, not only survival. One of the drugs used in stroke, including SAH, is Cerebrolysin. It is a mixture of neuropeptides that has similar properties to neurotrophic factors. Its positive impact on strokes has been analyzed; however, there are no meta-analyses concerning only the subpopulation of patients diagnosed with SAH in the current literature. Therefore, we conducted a meta-analysis of available clinical trials to evaluate the effect of Cerebrolysin on the treatment outcome. The data suggest a positive effect of Cerebrolysin on the mortality of SAH patients. However, further randomized clinical trials with larger groups of patients are needed to draw final conclusions. |
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In recent years, due to the development of endovascular and classical techniques, the mortality rate after SAH has decreased. Currently, more research is focused on understanding the molecular mechanisms underlying SAH. Methods of treatment are investigated in order to obtain the best treatment result, not only survival. One of the drugs used in stroke, including SAH, is Cerebrolysin. It is a mixture of neuropeptides that has similar properties to neurotrophic factors. Its positive impact on strokes has been analyzed; however, there are no meta-analyses concerning only the subpopulation of patients diagnosed with SAH in the current literature. Therefore, we conducted a meta-analysis of available clinical trials to evaluate the effect of Cerebrolysin on the treatment outcome. The data suggest a positive effect of Cerebrolysin on the mortality of SAH patients. However, further randomized clinical trials with larger groups of patients are needed to draw final conclusions.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12206638</identifier><identifier>PMID: 37892776</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Asymptomatic ; Bias ; Care and treatment ; Clinical medicine ; Clinical trials ; Complications and side effects ; Diagnosis ; Editorials ; Fistula ; Growth factors ; Hemorrhage ; Hormone replacement therapy ; Hypertension ; Intracranial aneurysms ; Meta-analysis ; Mortality ; Prevention ; Risk factors ; Smooth muscle ; Stroke ; Stroke (Disease) ; Subarachnoid hemorrhage ; Systematic Review ; Traumatic brain injury ; Tumor necrosis factor-TNF ; Veins & arteries</subject><ispartof>Journal of clinical medicine, 2023-10, Vol.12 (20), p.6638</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-15399e88c2a5891db21df79ebdb1e801028d0f51e21a3e392d9f6bd732e7a5553</citedby><cites>FETCH-LOGICAL-c477t-15399e88c2a5891db21df79ebdb1e801028d0f51e21a3e392d9f6bd732e7a5553</cites><orcidid>0000-0003-3193-1767 ; 0000-0001-5444-5150 ; 0000-0003-1935-5285 ; 0000-0002-2279-4329</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607250/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607250/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37892776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojder, Klaudyna</creatorcontrib><creatorcontrib>Jarosz, Konrad</creatorcontrib><creatorcontrib>Bosiacki, Mateusz</creatorcontrib><creatorcontrib>Andrzejewska, Agata</creatorcontrib><creatorcontrib>Zacha, Sławomir</creatorcontrib><creatorcontrib>Solek-Pastuszka, Joanna</creatorcontrib><creatorcontrib>Jurczak, Anna</creatorcontrib><title>Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Subarachnoid Hemorrhage (SAH) is one of the acute neurological conditions that is associated with high mortality and recovery failure rates. In recent years, due to the development of endovascular and classical techniques, the mortality rate after SAH has decreased. Currently, more research is focused on understanding the molecular mechanisms underlying SAH. Methods of treatment are investigated in order to obtain the best treatment result, not only survival. One of the drugs used in stroke, including SAH, is Cerebrolysin. It is a mixture of neuropeptides that has similar properties to neurotrophic factors. Its positive impact on strokes has been analyzed; however, there are no meta-analyses concerning only the subpopulation of patients diagnosed with SAH in the current literature. Therefore, we conducted a meta-analysis of available clinical trials to evaluate the effect of Cerebrolysin on the treatment outcome. The data suggest a positive effect of Cerebrolysin on the mortality of SAH patients. However, further randomized clinical trials with larger groups of patients are needed to draw final conclusions.</description><subject>Asymptomatic</subject><subject>Bias</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Editorials</subject><subject>Fistula</subject><subject>Growth factors</subject><subject>Hemorrhage</subject><subject>Hormone replacement therapy</subject><subject>Hypertension</subject><subject>Intracranial aneurysms</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Prevention</subject><subject>Risk factors</subject><subject>Smooth muscle</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>Subarachnoid hemorrhage</subject><subject>Systematic Review</subject><subject>Traumatic brain injury</subject><subject>Tumor necrosis factor-TNF</subject><subject>Veins & arteries</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl1rHCEUhqW0NCHNVe-L0JtCmdSPdXR6U5alTQIpKU17VxBHz-y6zGiiMwn77-vmq5tQFRR9zquv5yD0lpIjzhvyaW0Hyhipa65eoH1GpKwIV_zlznoPHea8JqUpNWNUvkZ7XKqGSVnvoz8LSNCm2G-yD7iMH2b0EMaMb_y4whdTa5KxqxC9wycwxJRWZgmf8RxfbPIIQ6Et_gnXHm6wCQ5_h9FU82C2evkNetWZPsPh_XyAfn_7-mtxUp2dH58u5meVnUk5VlTwpgGlLDNCNdS1jLpONtC6loIilDDlSCcoMGo48Ia5pqtbJzkDaYQQ_AB9udO9nNoBnC3vT6bXl8kPJm10NF4_PQl-pZfxWlNSE8kEKQof7hVSvJogj3rw2ULfmwBxypopxYUUjPKCvn-GruOUiuNbihUHjMz-UUvTg_ahi-ViuxXVcylLwgSlslBH_6FKdzB4GwN0vuw_Cfh4F2BTzDlB92iSEr0tCL1TEIV-t_svj-xD-vlfex2vSQ</recordid><startdate>20231020</startdate><enddate>20231020</enddate><creator>Kojder, Klaudyna</creator><creator>Jarosz, Konrad</creator><creator>Bosiacki, Mateusz</creator><creator>Andrzejewska, Agata</creator><creator>Zacha, Sławomir</creator><creator>Solek-Pastuszka, Joanna</creator><creator>Jurczak, Anna</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3193-1767</orcidid><orcidid>https://orcid.org/0000-0001-5444-5150</orcidid><orcidid>https://orcid.org/0000-0003-1935-5285</orcidid><orcidid>https://orcid.org/0000-0002-2279-4329</orcidid></search><sort><creationdate>20231020</creationdate><title>Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis</title><author>Kojder, Klaudyna ; 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subjects | Asymptomatic Bias Care and treatment Clinical medicine Clinical trials Complications and side effects Diagnosis Editorials Fistula Growth factors Hemorrhage Hormone replacement therapy Hypertension Intracranial aneurysms Meta-analysis Mortality Prevention Risk factors Smooth muscle Stroke Stroke (Disease) Subarachnoid hemorrhage Systematic Review Traumatic brain injury Tumor necrosis factor-TNF Veins & arteries |
title | Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis |
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