Longitudinal Changes in Mitochondrial DNA Copy Number and Telomere Length in Patients with Parkinson’s Disease

Parkinson’s disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and aging as its biggest risk factors. Mitochondrial DNA copy number (mtDNA-CN) and telomere length (TL) are biological aging markers with inconclusive results regarding their association with PD. A case–...

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Veröffentlicht in:	Genes 2023-10, Vol.14 (10), p.1913
Hauptverfasser:	Ortega-Vázquez, Alberto, Sánchez-Badajos, Salvador, Ramírez-García, Miguel Ángel, Alvarez-Luquín, Diana, López-López, Marisol, Adalid-Peralta, Laura Virginia, Monroy-Jaramillo, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Aging Analysis Biomarkers Blood tests Cell division Copy number Cytokines Development and progression Disease Dopamine Dopamine receptors Enzyme-linked immunosorbent assay Ethnicity Genetic testing Inflammation Longitudinal studies Mathematical models Mitochondrial DNA Movement disorders Neurodegeneration Neurodegenerative diseases Oxidative stress Parkinson's disease Patients Pramipexole Risk factors Telomerase Telomeres Type 2 diabetes Variance analysis
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