R-Loops in Genome Instability and Cancer

R-loops are unique, three-stranded nucleic acid structures that primarily form when an RNA molecule displaces one DNA strand and anneals to the complementary DNA strand in a double-stranded DNA molecule. R-loop formation can occur during natural processes, such as transcription, in which the nascent...

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Veröffentlicht in:	Cancers 2023-10, Vol.15 (20), p.4986
Hauptverfasser:	Li, Fang, Zafar, Alyan, Luo, Liang, Denning, Ariana Maria, Gu, Jun, Bennett, Ansley, Yuan, Fenghua, Zhang, Yanbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Care and treatment Cell cycle Cell death Cell proliferation Chromatin Chromosomes Class switching Development and progression DNA biosynthesis DNA damage DNA methylation DNA repair DNA replication Gene expression Genes Genetic aspects Genetic transcription Genomes Genomic instability Genomics Immunoglobulins Lung cancer Metabolism Microscopy Mitochondrial DNA Ovarian cancer Physiological aspects Physiology Prostate cancer Protein synthesis R-loops Review Ribosomal DNA RNA RNA polymerase RNA processing Single-stranded DNA Tumorigenesis
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