GDNF gene therapy for alcohol use disorder in male non-human primates

Alcohol use disorder (AUD) exacts enormous personal, social and economic costs globally. Return to alcohol use in treatment-seeking patients with AUD is common, engendered by a cycle of repeated abstinence-relapse episodes even with use of currently available pharmacotherapies. Repeated ethanol use...

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Veröffentlicht in:	Nature medicine 2023-08, Vol.29 (8), p.2030-2040
Hauptverfasser:	Ford, Matthew M., George, Brianna E., Van Laar, Victor S., Holleran, Katherine M., Naidoo, Jerusha, Hadaczek, Piotr, Vanderhooft, Lauren E., Peck, Emily G., Dawes, Monica H., Ohno, Kousaku, Bringas, John, McBride, Jodi L., Samaranch, Lluis, Forsayeth, John R., Jones, Sara R., Grant, Kathleen A., Bankiewicz, Krystof S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689 692/617/375 Ablation Abstinence Alcohol Drinking - genetics Alcohol Drinking - metabolism Alcohol use Alcoholism - drug therapy Alcoholism - therapy Alcohols Animals Biomedical and Life Sciences Biomedicine Cancer Research Circuits Dopamine Dopamine - metabolism Dopamine receptors Dopaminergic Neurons - metabolism Drinking Drinking behavior Economic impact Ethanol Ethanol - metabolism Ethanol - pharmacology Ethanol - therapeutic use Gene therapy Genetic Therapy Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor - genetics Growth factors Infectious Diseases Male Males Mesolimbic system Metabolic Diseases Molecular Medicine Neuronal-glial interactions Neurosciences Neurotrophic factors Nucleus accumbens Nucleus Accumbens - metabolism Primates Primates - genetics Reintroduction Ventral Tegmental Area - metabolism Ventral tegmentum
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