Synapse-Enriched m6A-Modified Malat1 Interacts with the Novel m6A Reader, DPYSL2, and Is Required for Fear-Extinction Memory

The RNA modification N6-methyladenosine (m6A) regulates the interaction between RNA and various RNA binding proteins within the nucleus and other subcellular compartments and has recently been shown to be involved in experience-dependent plasticity, learning, and memory. Using m6A RNA-sequencing, we...

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Veröffentlicht in:	The Journal of neuroscience 2023-10, Vol.43 (43), p.7084-7100
Hauptverfasser:	Madugalle, Sachithrani U, Liau, Wei-Siang, Zhao, Qiongyi, Li, Xiang, Gong, Hao, Marshall, Paul R, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L, Leighton, Laura J, Ren, Haobin, Musgrove, Mason R B, Davies, Joshua W A, Kim, Gwangmin, Rauch, Simone, He, Chuan, Dickinson, Bryan C, Fulopova, Barbora, Fletcher, Lee N, Williams, Stephen R, Spitale, Robert C, Bredy, Timothy W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Binding Dendritic spines Extinction behavior Fear Gene sequencing Immunoprecipitation Learning Mass spectrometry Mass spectroscopy Metastases N6-methyladenosine RNA modification RNA-binding protein Spine
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