Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

IMPORTANCE: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. OBJECTIVE: To determine whether vitamin C improves outcomes for patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: Two prospectively harmonized randomized clinical trials enrolled critically ill patie...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2023-11, Vol.330 (18), p.1745-1759
Hauptverfasser:	Adhikari, Neill K. J, Hashmi, Madiha, Tirupakuzhi Vijayaraghavan, Bharath Kumar, Haniffa, Rashan, Beane, Abi, Webb, Steve A, Angus, Derek C, Gordon, Anthony C, Cook, Deborah J, Guyatt, Gordon H, Berry, Lindsay R, Lorenzi, Elizabeth, Mouncey, Paul R, Au, Carly, Pinto, Ruxandra, Ménard, Julie, Sprague, Sheila, Masse, Marie-Hélène, Huang, David T, Heyland, Daren K, Nichol, Alistair D, McArthur, Colin J, de Man, Angelique, Al-Beidh, Farah, Annane, Djillali, Anstey, Matthew, Arabi, Yaseen M, Battista, Marie-Claude, Berry, Scott, Bhimani, Zahra, Bonten, Marc J. M, Bradbury, Charlotte A, Brant, Emily B, Brunkhorst, Frank M, Burrell, Aidan, Buxton, Meredith, Cecconi, Maurizio, Cheng, Allen C, Cohen, Dian, Cove, Matthew E, Day, Andrew G, Derde, Lennie P. G, Detry, Michelle A, Estcourt, Lise J, Fagbodun, Elizabeth O, Fitzgerald, Mark, Goossens, Herman, Green, Cameron, Higgins, Alisa M, Hills, Thomas E, Horvat, Christopher, Ichihara, Nao, Jayakumar, Devachandran, Kanji, Salmaan, Khoso, Muhammad Nasir, Lawler, Patrick R, Lewis, Roger J, Litton, Edward, Marshall, John C, McAuley, Daniel F, McGlothlin, Anna, McGuinness, Shay P, McQuilten, Zoe K, McVerry, Bryan J, Murthy, Srinivas, Parke, Rachael L, Parker, Jane C, Reyes, Luis Felipe, Rowan, Kathryn M, Saito, Hiroki, Salahuddin, Nawal, Santos, Marlene S, Saunders, Christina T, Seymour, Christopher W, Shankar-Hari, Manu, Tolppa, Timo, Trapani, Tony, Turgeon, Alexis F, Turner, Anne M, Udy, Andrew A, van de Veerdonk, Frank L, Zarychanski, Ryan, Lamontagne, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid - therapeutic use Bayes Theorem Caring for the Critically Ill Patient COVID-19 Critical Illness - mortality Critical Illness - therapy Female Hospital Mortality Humans Male Middle Aged Online First Original Investigation Randomized Controlled Trials as Topic Sepsis - drug therapy Vitamins - therapeutic use
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