Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report...
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| Veröffentlicht in: | Science advances 2023-10, Vol.9 (43), p.eadj1010-eadj1010 |
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| creator | Barone, Ilaria Gilette, Nicole M Hawks-Mayer, Hannah Handy, Jonathan Zhang, Kevin J Chifamba, Fortunate F Mostafa, Engie Johnson-Venkatesh, Erin M Sun, Yan Gibson, Jennifer M Rotenberg, Alexander Umemori, Hisashi Tsai, Peter T Lipton, Jonathan O |
| description | The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report that BMAL1 rhythmically localizes to hippocampal synapses in a manner dependent on its phosphorylation at Ser
[pBMAL1(S42)]. pBMAL1(S42) regulates the autophosphorylation of synaptic CaMKIIα and circadian rhythms of CaMKIIα-dependent molecular interactions and LTP but not global rest/activity behavior. Therefore, our results suggest a model in which repurposing of the clock protein BMAL1 to synapses locally gates the circadian timing of plasticity. |
| doi_str_mv | 10.1126/sciadv.adj1010 |
| format | Article |
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[pBMAL1(S42)]. pBMAL1(S42) regulates the autophosphorylation of synaptic CaMKIIα and circadian rhythms of CaMKIIα-dependent molecular interactions and LTP but not global rest/activity behavior. Therefore, our results suggest a model in which repurposing of the clock protein BMAL1 to synapses locally gates the circadian timing of plasticity.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.adj1010</identifier><identifier>PMID: 37878694</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>ARNTL Transcription Factors - genetics ; Circadian Clocks ; Circadian Rhythm - physiology ; Hippocampus - metabolism ; Molecular Biology ; Neuroscience ; Phosphorylation ; SciAdv r-articles</subject><ispartof>Science advances, 2023-10, Vol.9 (43), p.eadj1010-eadj1010</ispartof><rights>Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2023 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c346t-5b6083e0ed5f7b33ee696478657ceab57572b932511c59418372829ee328d6113</cites><orcidid>0000-0001-7198-2062 ; 0000-0002-9648-0541 ; 0000-0002-7328-3406 ; 0000-0002-0749-8492 ; 0000-0002-3120-3922 ; 0000-0003-2590-0737 ; 0000-0002-0729-9688 ; 0000-0002-7191-7268 ; 0009-0000-2182-0137 ; 0000-0001-5035-5801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599629/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599629/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37878694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barone, Ilaria</creatorcontrib><creatorcontrib>Gilette, Nicole M</creatorcontrib><creatorcontrib>Hawks-Mayer, Hannah</creatorcontrib><creatorcontrib>Handy, Jonathan</creatorcontrib><creatorcontrib>Zhang, Kevin J</creatorcontrib><creatorcontrib>Chifamba, Fortunate F</creatorcontrib><creatorcontrib>Mostafa, Engie</creatorcontrib><creatorcontrib>Johnson-Venkatesh, Erin M</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Gibson, Jennifer M</creatorcontrib><creatorcontrib>Rotenberg, Alexander</creatorcontrib><creatorcontrib>Umemori, Hisashi</creatorcontrib><creatorcontrib>Tsai, Peter T</creatorcontrib><creatorcontrib>Lipton, Jonathan O</creatorcontrib><title>Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report that BMAL1 rhythmically localizes to hippocampal synapses in a manner dependent on its phosphorylation at Ser
[pBMAL1(S42)]. pBMAL1(S42) regulates the autophosphorylation of synaptic CaMKIIα and circadian rhythms of CaMKIIα-dependent molecular interactions and LTP but not global rest/activity behavior. Therefore, our results suggest a model in which repurposing of the clock protein BMAL1 to synapses locally gates the circadian timing of plasticity.</description><subject>ARNTL Transcription Factors - genetics</subject><subject>Circadian Clocks</subject><subject>Circadian Rhythm - physiology</subject><subject>Hippocampus - metabolism</subject><subject>Molecular Biology</subject><subject>Neuroscience</subject><subject>Phosphorylation</subject><subject>SciAdv r-articles</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1LAzEQDaLYUnv1KHv00pqPzddJalErVDyo55DNpjYlu1mTbWH_vSutpR6GGZj33jzmAXCN4BQhzO6ScbrcTXW5QRDBMzDEhNMJprk4P5kHYJzSBkKIcsYokpdgQLjggsl8CBbvXa2b1pns4XW2RFmzDqmv2HndulBnJtRtDD5lxkWjS6frbO2aJhhdNdpnjdepJ7u2uwIXK-2THR_6CHw-PX7MF5Pl2_PLfLacGJKzdkILBgWx0JZ0xQtCrGWS5b0Zyo3VBeWU40ISTBEyVOZIEI4FltYSLEqGEBmB-71usy0qWxrb-9NeNdFVOnYqaKf-b2q3Vl9hpxCkUjIse4Xbg0IM31ubWlW5ZKz3urZhmxQWAhOcE8J66HQPNTGkFO3qeAdB9RuB2kegDhH0hJtTd0f438PJDxAahKM</recordid><startdate>20231027</startdate><enddate>20231027</enddate><creator>Barone, Ilaria</creator><creator>Gilette, Nicole M</creator><creator>Hawks-Mayer, Hannah</creator><creator>Handy, Jonathan</creator><creator>Zhang, Kevin J</creator><creator>Chifamba, Fortunate F</creator><creator>Mostafa, Engie</creator><creator>Johnson-Venkatesh, Erin M</creator><creator>Sun, Yan</creator><creator>Gibson, Jennifer M</creator><creator>Rotenberg, Alexander</creator><creator>Umemori, Hisashi</creator><creator>Tsai, Peter T</creator><creator>Lipton, Jonathan O</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7198-2062</orcidid><orcidid>https://orcid.org/0000-0002-9648-0541</orcidid><orcidid>https://orcid.org/0000-0002-7328-3406</orcidid><orcidid>https://orcid.org/0000-0002-0749-8492</orcidid><orcidid>https://orcid.org/0000-0002-3120-3922</orcidid><orcidid>https://orcid.org/0000-0003-2590-0737</orcidid><orcidid>https://orcid.org/0000-0002-0729-9688</orcidid><orcidid>https://orcid.org/0000-0002-7191-7268</orcidid><orcidid>https://orcid.org/0009-0000-2182-0137</orcidid><orcidid>https://orcid.org/0000-0001-5035-5801</orcidid></search><sort><creationdate>20231027</creationdate><title>Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity</title><author>Barone, Ilaria ; Gilette, Nicole M ; Hawks-Mayer, Hannah ; Handy, Jonathan ; Zhang, Kevin J ; Chifamba, Fortunate F ; Mostafa, Engie ; Johnson-Venkatesh, Erin M ; Sun, Yan ; Gibson, Jennifer M ; Rotenberg, Alexander ; Umemori, Hisashi ; Tsai, Peter T ; Lipton, Jonathan O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-5b6083e0ed5f7b33ee696478657ceab57572b932511c59418372829ee328d6113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ARNTL Transcription Factors - genetics</topic><topic>Circadian Clocks</topic><topic>Circadian Rhythm - physiology</topic><topic>Hippocampus - metabolism</topic><topic>Molecular Biology</topic><topic>Neuroscience</topic><topic>Phosphorylation</topic><topic>SciAdv r-articles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barone, Ilaria</creatorcontrib><creatorcontrib>Gilette, Nicole M</creatorcontrib><creatorcontrib>Hawks-Mayer, Hannah</creatorcontrib><creatorcontrib>Handy, Jonathan</creatorcontrib><creatorcontrib>Zhang, Kevin J</creatorcontrib><creatorcontrib>Chifamba, Fortunate F</creatorcontrib><creatorcontrib>Mostafa, Engie</creatorcontrib><creatorcontrib>Johnson-Venkatesh, Erin M</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Gibson, Jennifer M</creatorcontrib><creatorcontrib>Rotenberg, Alexander</creatorcontrib><creatorcontrib>Umemori, Hisashi</creatorcontrib><creatorcontrib>Tsai, Peter T</creatorcontrib><creatorcontrib>Lipton, Jonathan O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barone, Ilaria</au><au>Gilette, Nicole M</au><au>Hawks-Mayer, Hannah</au><au>Handy, Jonathan</au><au>Zhang, Kevin J</au><au>Chifamba, Fortunate F</au><au>Mostafa, Engie</au><au>Johnson-Venkatesh, Erin M</au><au>Sun, Yan</au><au>Gibson, Jennifer M</au><au>Rotenberg, Alexander</au><au>Umemori, Hisashi</au><au>Tsai, Peter T</au><au>Lipton, Jonathan O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity</atitle><jtitle>Science advances</jtitle><addtitle>Sci Adv</addtitle><date>2023-10-27</date><risdate>2023</risdate><volume>9</volume><issue>43</issue><spage>eadj1010</spage><epage>eadj1010</epage><pages>eadj1010-eadj1010</pages><issn>2375-2548</issn><eissn>2375-2548</eissn><abstract>The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. 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[pBMAL1(S42)]. pBMAL1(S42) regulates the autophosphorylation of synaptic CaMKIIα and circadian rhythms of CaMKIIα-dependent molecular interactions and LTP but not global rest/activity behavior. Therefore, our results suggest a model in which repurposing of the clock protein BMAL1 to synapses locally gates the circadian timing of plasticity.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>37878694</pmid><doi>10.1126/sciadv.adj1010</doi><orcidid>https://orcid.org/0000-0001-7198-2062</orcidid><orcidid>https://orcid.org/0000-0002-9648-0541</orcidid><orcidid>https://orcid.org/0000-0002-7328-3406</orcidid><orcidid>https://orcid.org/0000-0002-0749-8492</orcidid><orcidid>https://orcid.org/0000-0002-3120-3922</orcidid><orcidid>https://orcid.org/0000-0003-2590-0737</orcidid><orcidid>https://orcid.org/0000-0002-0729-9688</orcidid><orcidid>https://orcid.org/0000-0002-7191-7268</orcidid><orcidid>https://orcid.org/0009-0000-2182-0137</orcidid><orcidid>https://orcid.org/0000-0001-5035-5801</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | ARNTL Transcription Factors - genetics Circadian Clocks Circadian Rhythm - physiology Hippocampus - metabolism Molecular Biology Neuroscience Phosphorylation SciAdv r-articles |
| title | Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity |
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