Cholesterol catalyzes unfolding in membrane-inserted motifs of the pore forming protein cytolysin A

Plasma membrane-induced protein folding and conformational transitions play a central role in cellular homeostasis. Several transmembrane proteins are folded in the complex lipid milieu to acquire a specific structure and function. Bacterial pore forming toxins (PFTs) are proteins expressed by a lar...

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Veröffentlicht in:	Biophysical journal 2023-10, Vol.122 (20), p.4068-4081
Hauptverfasser:	Kulshrestha, Avijeet, Punnathanam, Sudeep N., Roy, Rahul, Ayappa, K. Ganapathy
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins Cell Membrane - metabolism Cholesterol - metabolism Cytotoxins - analysis Cytotoxins - metabolism Cytotoxins - pharmacology Escherichia coli - metabolism Porins - metabolism Protein Structure, Secondary
Online-Zugang:	Volltext
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