Proteasome inhibitors block development of Plasmodium spp

Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators of cell cycle progression. Here we show that nanomolar concentrations of lactacystin, a specific irreversible inhibitor of the 20S proteasome, inhibit development of the exoerythrocytic a...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 1998-10, Vol.42 (10), p.2731-2738
Hauptverfasser:	GANTT, S. M, JOON MO MYUNG, BRIONES, M. R. S, WEI DONG LI, COREY, E. J, OMURA, S, NUSSENZWEIG, V, SINNIS, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Cysteine Endopeptidases - drug effects Cysteine Proteinase Inhibitors - pharmacology Entamoeba Erythrocytes - parasitology Humans Hypoxanthine - metabolism Mechanisms of Action: Physiological Effects Medical sciences Multienzyme Complexes - drug effects Pharmacology. Drug treatments Plasmodium - drug effects Plasmodium - growth & development Plasmodium berghei Plasmodium falciparum Proteasome Endopeptidase Complex Rats Rats, Sprague-Dawley Trypanosoma
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