A wireless patch for the monitoring of C-reactive protein in sweat
The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its com...
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| Veröffentlicht in: | Nature biomedical engineering 2023-10, Vol.7 (10), p.1293-1306 |
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| creator | Tu, Jiaobing Min, Jihong Song, Yu Xu, Changhao Li, Jiahong Moore, Jeff Hanson, Justin Hu, Erin Parimon, Tanyalak Wang, Ting-Yu Davoodi, Elham Chou, Tsui-Fen Chen, Peter Hsu, Jeffrey J. Rossiter, Harry B. Gao, Wei |
| description | The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its composition. Here we report the design and performance of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The device integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein’s levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory proteins in sweat may facilitate the management of chronic diseases.
A wearable electrochemical patch for the real-time monitoring of the biomarker C-reactive protein in sweat detects elevated concentrations of the protein in patients with acute or chronic inflammation. |
| doi_str_mv | 10.1038/s41551-023-01059-5 |
| format | Article |
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A wearable electrochemical patch for the real-time monitoring of the biomarker C-reactive protein in sweat detects elevated concentrations of the protein in patients with acute or chronic inflammation.</description><identifier>ISSN: 2157-846X</identifier><identifier>EISSN: 2157-846X</identifier><identifier>DOI: 10.1038/s41551-023-01059-5</identifier><identifier>PMID: 37349389</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/166/985 ; 639/301/1005 ; 639/638/11 ; 639/925/930 ; 9/10 ; Antibodies ; Biomarkers ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biosensors ; C-reactive protein ; C-Reactive Protein - analysis ; C-Reactive Protein - metabolism ; Chronic illnesses ; Chronic obstructive pulmonary disease ; Congestive heart failure ; Electrochemical analysis ; Gold ; Graphene ; Humans ; Inflammation ; Ionic strength ; Lung diseases ; Metal Nanoparticles ; Microfluidics ; Monitoring ; Monitoring, Physiologic ; Nanoparticles ; Obstructive lung disease ; Proteins ; Reagents ; Real time ; Sensor arrays ; Sweat ; Sweat - chemistry ; Telemedicine ; Wearable Electronic Devices ; Wearable technology</subject><ispartof>Nature biomedical engineering, 2023-10, Vol.7 (10), p.1293-1306</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f153d87693d791e0a3da116e2eaad4c3d23a1fbecf4fabb888a068c3d8c8936e3</citedby><cites>FETCH-LOGICAL-c475t-f153d87693d791e0a3da116e2eaad4c3d23a1fbecf4fabb888a068c3d8c8936e3</cites><orcidid>0000-0002-8503-4562 ; 0000-0002-5647-7954 ; 0000-0002-6817-3341 ; 0000-0002-8867-6632 ; 0000-0002-5788-1473 ; 0000-0002-7884-0726 ; 0000-0002-4185-2256 ; 0009-0004-8806-9105</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41551-023-01059-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41551-023-01059-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37349389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Jiaobing</creatorcontrib><creatorcontrib>Min, Jihong</creatorcontrib><creatorcontrib>Song, Yu</creatorcontrib><creatorcontrib>Xu, Changhao</creatorcontrib><creatorcontrib>Li, Jiahong</creatorcontrib><creatorcontrib>Moore, Jeff</creatorcontrib><creatorcontrib>Hanson, Justin</creatorcontrib><creatorcontrib>Hu, Erin</creatorcontrib><creatorcontrib>Parimon, Tanyalak</creatorcontrib><creatorcontrib>Wang, Ting-Yu</creatorcontrib><creatorcontrib>Davoodi, Elham</creatorcontrib><creatorcontrib>Chou, Tsui-Fen</creatorcontrib><creatorcontrib>Chen, Peter</creatorcontrib><creatorcontrib>Hsu, Jeffrey J.</creatorcontrib><creatorcontrib>Rossiter, Harry B.</creatorcontrib><creatorcontrib>Gao, Wei</creatorcontrib><title>A wireless patch for the monitoring of C-reactive protein in sweat</title><title>Nature biomedical engineering</title><addtitle>Nat. Biomed. Eng</addtitle><addtitle>Nat Biomed Eng</addtitle><description>The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its composition. Here we report the design and performance of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The device integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein’s levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory proteins in sweat may facilitate the management of chronic diseases.
A wearable electrochemical patch for the real-time monitoring of the biomarker C-reactive protein in sweat detects elevated concentrations of the protein in patients with acute or chronic inflammation.</description><subject>639/166/985</subject><subject>639/301/1005</subject><subject>639/638/11</subject><subject>639/925/930</subject><subject>9/10</subject><subject>Antibodies</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biosensors</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>C-Reactive Protein - metabolism</subject><subject>Chronic illnesses</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Congestive heart failure</subject><subject>Electrochemical analysis</subject><subject>Gold</subject><subject>Graphene</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Ionic strength</subject><subject>Lung diseases</subject><subject>Metal Nanoparticles</subject><subject>Microfluidics</subject><subject>Monitoring</subject><subject>Monitoring, Physiologic</subject><subject>Nanoparticles</subject><subject>Obstructive lung disease</subject><subject>Proteins</subject><subject>Reagents</subject><subject>Real time</subject><subject>Sensor arrays</subject><subject>Sweat</subject><subject>Sweat - chemistry</subject><subject>Telemedicine</subject><subject>Wearable Electronic Devices</subject><subject>Wearable technology</subject><issn>2157-846X</issn><issn>2157-846X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1LxDAQhoMoKrp_wIMEvHip5qNpk5Po4hcIXhS8hWw6dSPdpiZZxX9v1tX14yAEMmSeeTMzL0J7lBxRwuVxLKkQtCCMF4QSoQqxhrYZFXUhy-ph_Ue8hUYxPhFCqOKlqsUm2uJ1jrhU2-jsFL-6AB3EiAeT7BS3PuA0BTzzvUs-uP4R-xaPiwDGJvcCeAg-getxPvEVTNpFG63pIow-7x10f3F-N74qbm4vr8enN4Uta5GKlgreyLpSvKkVBWJ4YyitgIExTWl5w7ih7QRsW7ZmMpFSGlLJ_C6tVLwCvoNOlrrDfDKDxkKfgun0ENzMhDftjdO_M72b6kf_ohfrYayiWeHwUyH45znEpGcuWug604OfR80kUyVTUrGMHvxBn_w89Hm-TNWqrCpKVKbYkrLBxxigXXVDiV7YpJc26WyT_rBJi1y0_3OOVcmXKRngSyAOi_VD-P77H9l3HR2eGw</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Tu, Jiaobing</creator><creator>Min, Jihong</creator><creator>Song, Yu</creator><creator>Xu, Changhao</creator><creator>Li, Jiahong</creator><creator>Moore, Jeff</creator><creator>Hanson, Justin</creator><creator>Hu, Erin</creator><creator>Parimon, Tanyalak</creator><creator>Wang, Ting-Yu</creator><creator>Davoodi, Elham</creator><creator>Chou, Tsui-Fen</creator><creator>Chen, Peter</creator><creator>Hsu, Jeffrey J.</creator><creator>Rossiter, Harry B.</creator><creator>Gao, Wei</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8503-4562</orcidid><orcidid>https://orcid.org/0000-0002-5647-7954</orcidid><orcidid>https://orcid.org/0000-0002-6817-3341</orcidid><orcidid>https://orcid.org/0000-0002-8867-6632</orcidid><orcidid>https://orcid.org/0000-0002-5788-1473</orcidid><orcidid>https://orcid.org/0000-0002-7884-0726</orcidid><orcidid>https://orcid.org/0000-0002-4185-2256</orcidid><orcidid>https://orcid.org/0009-0004-8806-9105</orcidid></search><sort><creationdate>20231001</creationdate><title>A wireless patch for the monitoring of C-reactive protein in sweat</title><author>Tu, Jiaobing ; 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Biomed. Eng</stitle><addtitle>Nat Biomed Eng</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>7</volume><issue>10</issue><spage>1293</spage><epage>1306</epage><pages>1293-1306</pages><issn>2157-846X</issn><eissn>2157-846X</eissn><abstract>The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its composition. Here we report the design and performance of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The device integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein’s levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory proteins in sweat may facilitate the management of chronic diseases.
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| subjects | 639/166/985 639/301/1005 639/638/11 639/925/930 9/10 Antibodies Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biosensors C-reactive protein C-Reactive Protein - analysis C-Reactive Protein - metabolism Chronic illnesses Chronic obstructive pulmonary disease Congestive heart failure Electrochemical analysis Gold Graphene Humans Inflammation Ionic strength Lung diseases Metal Nanoparticles Microfluidics Monitoring Monitoring, Physiologic Nanoparticles Obstructive lung disease Proteins Reagents Real time Sensor arrays Sweat Sweat - chemistry Telemedicine Wearable Electronic Devices Wearable technology |
| title | A wireless patch for the monitoring of C-reactive protein in sweat |
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