Germline Mutations in 12 Genes and Risk of Ovarian Cancer in Three Population-Based Cohorts

With the widespread use of multigene panel genetic testing, population-based studies are necessary to accurately assess penetrance in unselected individuals. We evaluated the prevalence of germline pathogenic or likely pathogenic variants (mutations) in 12 cancer-predisposition genes and association...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2023-10, Vol.32 (10), p.1402-1410
Hauptverfasser:	Kotsopoulos, Joanne, Hathaway, Cassandra A, Narod, Steven A, Teras, Lauren R, Patel, Alpa V, Hu, Chunling, Yadav, Siddhartha, Couch, Fergus J, Tworoger, Shelley S
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 Protein - genetics BRCA2 Protein - genetics Breast Neoplasms - genetics Carcinoma, Ovarian Epithelial - genetics Female Genetic Predisposition to Disease Genetic Testing Germ-Line Mutation Humans Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Prospective Studies
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