Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions

Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that androgen receptor (AR) forms condensates through multivalent interactions mediated by its N...

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Veröffentlicht in:	Molecular cell 2023-10, Vol.83 (19), p.3438-3456.e12
Hauptverfasser:	Chen, Lizhen, Zhang, Zhao, Han, Qinyu, Maity, Barun K., Rodrigues, Leticia, Zboril, Emily, Adhikari, Rashmi, Ko, Su-Hyuk, Li, Xin, Yoshida, Shawn R., Xue, Pengya, Smith, Emilie, Xu, Kexin, Wang, Qianben, Huang, Tim Hui-Ming, Chong, Shasha, Liu, Zhijie
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor condensate formation condensation enhancer Enhancer Elements, Genetic hormone-induced enhancer assembly Hormones Humans intrinsically disordered region multivalent interaction phase separation Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism
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