CHEK2 signaling is the key regulator of oocyte survival after chemotherapy

Cancer treatments can damage the ovarian follicle reserve, leading to primary ovarian insufficiency and infertility among survivors. Checkpoint kinase 2 (CHEK2) deficiency prevents elimination of oocytes in primordial follicles in female mice exposed to radiation and preserves their ovarian function...

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Veröffentlicht in:	Science advances 2023-10, Vol.9 (42), p.eadg0898-eadg0898
Hauptverfasser:	Emori, Chihiro, Boucher, Zachary, Bolcun-Filas, Ewelina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biomedicine and Life Sciences Cancer Checkpoint Kinase 2 - genetics Female Life Sciences Mice Oocytes - physiology Ovarian Follicle Ovary - physiology SciAdv r-articles
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