Cell-free DNA Methylation as a Predictive Biomarker of Response to Neoadjuvant Chemotherapy for Patients with Muscle-invasive Bladder Cancer in SWOG S1314

As a proof of concept, we demonstrated that cell-free DNA methylation can be used to generate artificial intelligence–based classifiers associated with response to neoadjuvant chemotherapy (NAC) in patients with muscle-invasive bladder cancer. With further validation, this approach may help assess w...

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Veröffentlicht in:	European urology oncology 2023-10, Vol.6 (5), p.516-524
Hauptverfasser:	Lu, Yi-Tsung, Plets, Melissa, Morrison, Gareth, Cunha, Alexander T., Cen, Steven Y., Rhie, Suhn K., Siegmund, Kimberly D., Daneshmand, Siamak, Quinn, David I., Meeks, Joshua J., Lerner, Seth P., Petrylak, Daniel P., McConkey, David, Flaig, Thomas W., Thompson, Ian M., Goldkorn, Amir
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Cell-free DNA Cell-Free Nucleic Acids - genetics Chemotherapy, Adjuvant DNA - therapeutic use DNA Methylation Humans Machine learning Methylation Muscle-invasive bladder cancer Muscles - pathology Neoadjuvant chemotherapy Neoadjuvant Therapy Predictive biomarker Prospective Studies Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology
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