Sulfamate-tethered aza-Wacker approach towards analogs of Bactobolin A

Here, we describe an approach towards analogs of the potent antibiotic Bactobolin A. Sulfamate-tethered aza -Wacker cyclization reactions furnish key synthons, which we envision can be elaborated into analogs of Bactobolin A. Docking studies show that the C4 epimer of Bactobolin A and the C4/C6 dias...

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Veröffentlicht in:	Medicinal chemistry research 2021-07, Vol.30 (7), p.1348-1357
Hauptverfasser:	Nagamalla, Someshwar, Johnson, David K., Sathyamoorthi, Shyam
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Antibiotics Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Chemical reactions Inorganic Chemistry Medicinal Chemistry Natural products Original Research Pharmacology/Toxicology rRNA rRNA 23S
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