Bronchopulmonary penetration of isavuconazole in lung transplant recipients
Isavuconazole’s (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h resp...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2023-10, Vol.67 (10), p.e0061323-e0061323 |
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| creator | Caballero-Bermejo, Antonio F. Darnaude-Ximénez, Ignacio Aguilar-Pérez, Myriam Gomez-Lopez, Alicia Sancho-López, Aránzazu López García-Gallo, Cristina Díaz Nuevo, Gema Diago-Sempere, Elena Ruiz-Antorán, Belén Avendaño-Solá, Cristina Ussetti-Gil, Piedad |
| description | Isavuconazole’s (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung. |
| doi_str_mv | 10.1128/aac.00613-23 |
| format | Article |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Pharmacology |
| title | Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
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